[Correspondence] Efficacy of antipsychotic drugs for schizophrenia – Authors' reply

Philippe Vincent and Edouard Kouassi make a valid point about the complex pharmacokinetics of some newer antipsychotic drugs. We believe that knowledge of these pharmacokinetics is essential for getting the best results from treatment and that these issues might be under-recognised in clinical practice. For example, even though the majority of the trials included in our meta-analysis were phase 3 studies with strict protocols, it cannot be ruled out that ziprasidone or lurasidone were sometimes taken without sufficient food.

Source: LANCET - December 7, 2013 Category: Journals (General) Authors: Stefan Leucht, Andrea Cipriani, John R Geddes, Georgia Salanti, John M Davis Tags: Correspondence Source Type: research