Riluzole Exhibits No Therapeutic Efficacy On a Transgenic Rat model of Amyotrophic Lateral Sclerosis.

CONCLUSION: These findings indicate that transgenic rats recapitulate the basic neurological and neuropathological characteristics of human ALS, while Riluzole treatment can not halt the development of the behavioral and histopathological phenotypes in this new transgenic rodent model of ALS.
PMID: 32271694 [PubMed - as supplied by publisher]

Source: Current Neurovascular Research - April 8, 2020 Category: Neurology Authors: Chen S, Liao Q, Lu K, Zhou J, Huang C, Bi F Tags: Curr Neurovasc Res Source Type: research