Role of the sympathetic nervous system in pain

Abstract: The involvement of the sympathetic nervous system in chronic pain conditions has been well described and recognized for over a century. However, the exact mechanism of the relationship has not been fully explained. In certain chronic pain conditions (e.g. complex regional pain syndrome (CRPS)), the presence of sympathetic signs forms part of the diagnostic criteria.Typical management will involve a multidisciplinary approach, including physical, pharmacological, and psychological therapies. Interventional techniques such as sympathetic blocks can also be used; however evidence of efficacy for many treatments remains poor.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Authors: Tags: Pain Source Type: research

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We report PMPS in a 39-year-old patient after revision operation of breast reduction surgery. Postoperatively, the patient showed symptoms of severe persistent pain, swelling, cutaneous temperature changes, and hyperhidrosis in the affected breast. Subcutaneous infiltration with triamcinolone acetonide and prilocaine only relieved the symptoms temporarily. Botox injections did not relieve her symptoms of sweating either. Two intercostal nerve branches were identified with ultrasonography and dissected in general anesthesia. This procedure relieved her symptoms. Surgeons should consider CRPS and PMPS as differential diagnos...
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
AbstractPurpose of ReviewThe world faces a crisis in pain management. CRPS is a multifaceted painful disorder, which is difficult to treat and resolve. Ozone therapy has unique mechanisms of actions that may directly address the emerging discoveries of factors related to pathogenesis of the disorder and other pain conditions. These include oxygenation, immune modulation, anti-infective properties, and anti-inflammatory properties. This review is to present ozone therapy as a novel approach for pain treatment, including CRPS.Recent FindingsOzone therapy has been found, in basic science studies, to ameliorate many of the mec...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
Conclusions: Acupuncture therapy seems effective for motor function, pain relief and activities of daily living in stroke patients with mild SHS, when it is used in combination with rehabilitation. The low certainty of evidence downgrades our confidence in making recommendations to clinical practice. Introduction Shoulder-hand syndrome (SHS) is a common condition among people who have had a stroke, with its reported prevalence ranging from 12% to 49% (1, 2). The main symptoms of SHS include pain, hyperalgesia, joint swelling and limitations in range of motion (ROM) (3). Post-stroke SHS is also named type I complex ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Pulsed radiofrequency (PRF) to the thoracic sympathetic ganglion (TSG PRF) or to the cervical sympathetic chain (CSC PRF) can be performed to overcome transient effects of single sympathetic blocks in patients with upper-extremity complex regional pain syndrome (CRPS). We retrospectively compared the clinical effects of TSG PRF and CSC PRF. Seven TSG PRF cases and 10 CSC PRF cases were enrolled in the present analysis. We assessed effectiveness with multiple clinical measurements: a numerical rating scale (NRS) of pain before and 1 week after the procedure, postprocedure temperature, effect duration, and a self-described ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: Available online 11 January 2019Source: Autoimmunity ReviewsAuthor(s): Christopher Chang, Patrick McDonnell, M. Eric GershwinAbstractComplex regional pain syndrome (CRPS) has been considered to be an autoimmune disease and there have been clinical trials with intravenous immunoglobulin. Often the etiology of the so-called CRPS diagnosis cannot be discerned and there are no validated instruments that provide functional metrics. The term complex regional pain syndrome (CRPS), coined in 1994 to describe patients in whom the pain is out of proportion to the injury, was actually a diagnosis proposed during the...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Vectris(TM) Trial Screening Lead Kit for Spinal Cord Stimulation, Models: (a) 977D160 (b) 977D260 Product Usage: The Medtronic Vectris lead kits contain the implantable spinal cord stimulation lead, as well as additional components used for lead implant as part of a Neurostimulation system for pain therapy. A Medtronic implantable Neurostimulation system is indicated for spinal cord stimulation (SCS) systems as an aid in the management of chronic, intractable pain of the trunk and/or limbs-including unilateral or bilateral pain associated with the following conditions: Failed Back Syndrome (FBS) or low back syndrome or fai...
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
Abstract A health educator who has reflex sympathetic dystrophy, an autoimmune condition involving chronic pain, shares her knowledge about living life to the fullest while dealing with a chronic health condition. Her advice encompasses dealing with the health care system, managing information, and obtaining physical and emotional self-care. PMID: 29669658 [PubMed - in process]
Source: Creative Nursing - Category: Nursing Authors: Tags: Creat Nurs Source Type: research
CONCLUSION: As a result; our study and the other studies show that SCS is reliable and effective procedure on chronic pain management. PMID: 28467566 [PubMed - in process]
Source: Agri Dergisi - Category: Anesthesiology Tags: Agri Source Type: research
CRPS (Complex regional pain syndrome) is a debilitating pain disorder characterized by allodynia, hyperalgesia and trophic changes. It has been sub classified into CRPS type I and type II. While CRPS type II is considered to be caused by a prior nerve injury, CRPS type I, also known as reflex sympathetic dystrophy is a poorly understood medical condition with no definitive identifiable etiology. Studies have shown that patients with depression have an increased rate of having chronic pain, including CRPS.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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