Inflammatory bowel disease: A key role for microbiota?

Publication date: Available online 10 April 2020Source: Meta GeneAuthor(s): Rana Zareef, Nour Younis, Rami Mahfouz
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research

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Publication date: September 2020Source: Pharmacological Research, Volume 159Author(s): Paolo Giuffrida, Antonio Di Sabatino
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusion: The results of this analysis can serve as a foundation to introduce HRQoL-based recommendations for the use of biologics in the management of IBD in Saudi Arabia. PMID: 32619388 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Abstract Inflammatory bowel disease, which typically manifests as Crohn's disease and ulcerative colitis, is caused by the abnormal production of cytokines such as tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β. These cytokines damage intestinal epithelial cells and trigger fibrosis, respectively, for which the current in vitro models have many limitations. Therefore, we tested whether human induced pluripotent stem cell-derived intestinal organoids (HiOs) can mimic inflammatory bowel disease (IBD), and whether such a model is suitable for drug screening. HiOs were treated with TNF...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Authors: Manceur AM, Ding Z, Muser E, Obando C, Voelker J, Pilon D, Kinkead F, Lafeuille MH, Lefebvre P Abstract Aims: To quantify the long-term direct and indirect costs among patients with Crohn's disease (CD) and specific subgroups of these patients in the United States from the private payer's perspective.Materials and Methods: This retrospective study used the OptumHealth Care Solutions, Inc database (01/01/1999-03/31/2017) to match (1:5) adult patients with ≥2 claims for CD to patients without inflammatory bowel disease (IBD). Patterns observed during follow-up (i.e., biologics, opioids, or steroids; CD-re...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Conclusions: PTL ameliorated colon inflammation in a gut microbiota-dependent manner. The underlying protective mechanism was associated with the improved Treg/Th17 balance in intestinal mucosa mediated through the increased microbiota-derived SCFAs production. Collectively, our results demonstrated the role of PTL as a potential gut microbiota modulator to prevent and treat IBD.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: The results of our study suggest that low-dose IL-2 has therapeutic effects on DSS-induced colitis and potential clinical value in treating UC.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: The CS-IGF-1C hydrogel improved the engraftment of transplanted hP-MSCs, ameliorated inflammatory responses, and further promoted the functional and structural recovery of colitis through PGE2-mediated M2 macrophage polarization. Molecular imaging approaches and therapeutic strategies for hydrogel application provide a versatile platform for exploring the promising therapeutic potential of MSCs in the treatment of IBD.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
AbstractPurpose of ReviewTo report the association between desquamative inflammatory vaginitis and Crohn ’s disease in 4 women.Recent FindingsExtraintestinal manifestations of inflammatory bowel disease (IBD) are a result of a complex interplay of multiple factors and these may or may not follow an independent course. Vulvar sequelae of Crohn ’s disease have been described in the literature, but the impact of IBD on vaginal health is not well known.SummaryIn all 4 patients, Crohn ’s disease diagnosis was known to the patients, all of whom were managed by experienced gastroenterologists. However, the assoc...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
AbstractUlcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflammation during the development of UC. In addition, whether C3a/C3aR axis could affect the development of UC by modulating the expression of caspase-11 is unclear. We established the UC rat model in this study. Next, the C3aR inhibitor was used to treat these rats at diverse stages of UC. Next, the HE st...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
ConclusionFecal calprotectin may be a reliable diagnostic tool for acute pouchitis in patients following TPC with IPAA for UC. The high sensitivity of fecal calprotectin for detection of pouchitis makes it a valuable test for ruling out pouchitis. When used in conjunction with other biomarkers, the high specificity offers value in ruling in pouchitis. However, given the complexity of this disease process, relying solely on biomarkers for diagnosis is currently unreasonable.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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