Progress in nicotinic receptor structural biology.

Progress in nicotinic receptor structural biology. Neuropharmacology. 2020 Apr 07;:108086 Authors: Gharpure A, Noviello CM, Hibbs RE Abstract Here we begin by briefly reviewing landmark structural studies on the nicotinic acetylcholine receptor. We highlight challenges that had to be overcome to push through resolution barriers, then focus on what has been gleaned in the past few years from crystallographic and single particle cryo-EM studies of different nicotinic receptor subunit assemblies and ligand complexes. We discuss insights into ligand recognition, ion permeation, and allosteric gating. We then highlight some foundational aspects of nicotinic receptor structural biology that remain unresolved and are areas ripe for future exploration. PMID: 32272141 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32272141?dopt=Abstract

Source: Neuropharmacology - April 6, 2020 Category: Drugs & Pharmacology Authors: Gharpure A, Noviello CM, Hibbs RE Tags: Neuropharmacology Source Type: research