Peptide Hormone Regulation of DNA Damage Responses.

Peptide Hormone Regulation of DNA Damage Responses. Endocr Rev. 2020 Apr 09;: Authors: Chesnokova V, Melmed S Abstract DNA damage response (DDR) and repair pathways determine neoplastic cell transformation and therapeutic responses, as well as the aging process. Altered DDR functioning results in accumulation of unrepaired DNA damage, increased frequency of tumorigenic mutations, and premature aging. Recent evidence suggests that polypeptide hormones play a role in modulating DDR and DNA damage repair, while DNA damage accumulation may also affect hormonal status. We review the available reports elucidating involvement of IGF1, GH, αMSH, and GnRH/gonadotrophins in DDR and DNA repair as well as the current understanding of pathways enabling these actions. We discuss effects of DNA damage pathway mutations, including Fanconi anemia, on endocrine function and consider mechanisms underlying these phenotypes. PMID: 32270196 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research