Sperm blocking study brings 'male pill' closer

Conclusion This laboratory study has investigated the effects on male fertility of a blocked ejaculation process following the depletion of two genes in a group of genetically modified mice. As the researchers say, there is a need for different approaches to male contraception because most strategies have so far focused on hormonal approaches that produce dysfunctional sperm. The researchers say these often have intolerable side effects, such as affecting male sexual activity or causing long-term irreversible effects on infertility. This laboratory study demonstrated that 100% male infertility was achieved among a group of genetically modified mice, with no negative effects on sexual behaviours or sperm function. The researchers say the same effects could be achieved using oral drugs. This is where the findings become more relevant to humans. The researchers point that one of the two targets, the α1A-adrenoceptor, already has a drug that selectively inhibits its action. This group of drugs – alpha blockers, such as Tamsulosin – are taken orally and are currently licensed for the treatment of benign prostate hyperplasia (non-cancerous swelling of the prostate gland). However, although alpha blockers have the same target, they are not contraceptive pills and have various cautions for their use, as well as associated side effects, one of which is erectile dysfunction – not ideal in a contraceptive. Therefore, it should not be wrongly assumed that we are already ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Medication Lifestyle/exercise Source Type: news