[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].

[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors]. Nervenarzt. 2020 Apr 07;: Authors: Kittel-Schneider S, Reif A Abstract All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety and in particular affective disorders. In these investigations the risk for one of these comorbid disorders increased with increasing age of the ADHD patients. The most recent genome-wide association and correlation studies also revealed indications for joint genetic risk factors of ADHD with, in particular unipolar depression, bipolar disorder, autism spectrum disorders, Tourette's syndrome and to a lesser extent schizophrenia. The only psychiatric disorder that was negatively correlated with ADHD was anorexia nervosa. Additionally, cannabis and cocaine use were significantly positively genetically correlated with ADHD. Furthermore, an increased occurrence of some specific somatic diseases could be found in patients with adult ADHD. In particular, obesity, migraine, sleep disorders, asthma and celiac disease showed a significantly positive association with ADHD in several studies. No association was found between ADHD and cardiovascular disease. Here as well there are initial indications of joint genetic risk variants; however, data are still sparse and additional studies ...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research