Comprehensive Profiling of Zika Virus Risk, United States Comprehensive Profiling of Zika Virus Risk, United States

A newly developed model to profile risk for Zika virus emergence provides important information for prevention efforts and resource utilization.Emerging Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

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Authors: Gorry C Abstract Meningitis, neuropathy, HIV, dengue-since the 1960s, Cuba has faced its share of epidemics. More recently, Cuban health pro-fessionals tackled domestic outbreaks of H1N1 (2009) and Zika (2016), and worked alongside colleagues from around the world to stem Ebola in West Africa; all three were categorized by WHO as public health emergencies of international concern. In December 2019, China reported its fi rst cluster of pneumo-nia cases, later identifi ed as the novel coronavirus disease COVID-19. In January 2020, Cuban authorities convened a multi-sector working group coordinated by the Min...
Source: MEDICC Review - Category: International Medicine & Public Health Tags: MEDICC Rev Source Type: research
Publication date: Available online 31 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ana Márcia Menezes de Oliveira, Elisama Gomes Magalhães de Melo, Mário Luis Tavares Mendes, Sheila Jaqueline Gomes dos Santos Oliveira, Carolina Santos Souza Tavares, Andreia Centenaro Vaez, Sara Juliana Abreu de Vasconcelos, Hudson P. Santos, Victor Santana Santos, Paulo Ricardo Saquete Martins-Filho
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Nazira El-Hage Here, we used a mouse model with defective autophagy to further decipher the role of autophagy in the infection and disease of Zika virus (ZIKV)-R103451. Hemizygous (Becn1+/−) and wild-type (Becn1+/+) pregnant mice were transiently immunocompromised using the anti-interferon alpha/beta receptor subunit 1 monoclonal antibody (MAR1-5A3). Despite a low mortality rate among the infected dams, 25% of Becn1+/− offspring were smaller in size and had smaller, underdeveloped brains. This phenotype became apparent after 2-to 3-weeks post-birth. Furthermore, the smaller-sized pups showed a de...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Elevated levels of a neurotoxin in northeastern Brazil's drinking water and a high incidence of microcephaly in the region led scientists to look for a link, and they found one.
Source: The Scientist - Category: Science Tags: Notebook Magazine Issue Source Type: news
The zika fever is a self-limiting disease caused by the Zika virus (ZIKV) infection, which is transmitted by Aedes aegypti (Weaver et al. 2016). As the first reported epidemics happened in African and Asian continents, ZIKV is classically classified in three lineages: East African, West African, and Asian. Moreover, the Asian lineage is further classified by geographical origin as Micronesian, Cambodian and Malaysian (Haddow et al., 2012). The strains isolated during the outbreak in Brazil were classified as Asian lineage (Faria et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Short Communication Source Type: research
The aim of this study was to investigate oral and maxillofacial outcomes in children with congenital Zika syndrome (CZS) and the presence of nonnutritive sucking habits, functional habits, and features related to breastfeeding and nutrition of these children.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
Publication date: Available online 29 May 2020Source: Neurología (English Edition)Author(s): L. del Carpio Orantes
Source: Neurologia - Category: Neurology Source Type: research
Gil Oliva Single-stranded positive RNA ((+) ssRNA) viruses include several important human pathogens. Some members are responsible for large outbreaks, such as Zika virus, West Nile virus, SARS-CoV, and SARS-CoV-2, while others are endemic, causing an enormous global health burden. Since vaccines or specific treatments are not available for most viral infections, the discovery of direct-acting antivirals (DAA) is an urgent need. Still, the low-throughput nature of and biosafety concerns related to traditional antiviral assays hinders the discovery of new inhibitors. With the advances of reverse genetics, reporter re...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Publication date: Available online 28 May 2020Source: Neurología (English Edition)Author(s): S. Yasri, V. Wiwanitkit
Source: Neurologia - Category: Neurology Source Type: research
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