Recognizing BCC on Smartphone-captured Digital Histopathology Recognizing BCC on Smartphone-captured Digital Histopathology
A novel approach using deep neural network frameworks shows promise for the diagnosis of basal-cell carcinoma via a smartphone camera.The British Journal of Dermatology
Abstract Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disorder of the pilosebaceous units. To date, studies on the risk of keratinocyte carcinoma (KC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), among HS patients have been limited. We performed a case-control study comparing the incidence of BCC and SCC in HS patients (cases) to that in acne vulgaris patients (controls), which is also an inflammatory disorder of the pilosebaceous unit. PMID: 32473027 [PubMed - as supplied by publisher]
CONCLUSION The authors' data very clearly demonstrate a higher rate of MH in sBCC of the head and neck which provides strong support to the current MAUC scoring.
CONCLUSION The present study demonstrated that a 4-mm resection margin was enough to eradicate the lesion completely in 99% of cases of primary small facial BCCs with aggressive histological patterns.
This case-control study assesses multiple aggregated yellow-white globules as a diagnostic feature for basal cell carcinoma.
Conclusion: Our patient, diagnosed with recurrent prostate BCC after receiving a radical prostatectomy, responded to treatment with etoposide. Radical prostatectomy and radiotherapy should remain first-line therapy; however, etoposide may be an alternative second-line therapy when other options are not available. Consensus regarding treatment plans, and the molecular mechanisms behind prostate BBC, must be elucidated.
ConclusionCurrent smoking and heavy smoking were associated with a higher risk of SCC but a decreased risk of BCC and MM, while former smoking was not associated with skin cancer risk.
Non-melanoma skin cancer (NMSC) is the most common cancer in fair-skinned adults and comprises basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC). Its incidence reaches 1/100 person-year in Australia (Lomas et al. 2012), and is still on the rise worldwide (Madan et al. 2010). Development of NMSC depends on genetic and environmental factors. Particularly, there is clear evidence that cumulative sun exposure contributes to the development of NMSC (Ananthaswamy et al. 1997; Madan et al. 2010).
AbstractSkin cancers remain the most common group of cancers globally, and the incidence continues to rise. Although localized skin cancers tend to have excellent outcomes following surgical excisions, the less common cases that become surgically unresectable or metastatic have been associated with poor prognosis and suboptimal treatment responses to cytotoxic chemotherapy. Development of monoclonal antibodies to programmed cell death-1 receptor and its ligand (PD-1/PD-L1) have transformed the management of metastatic melanoma, squamous cell carcinoma, and Merkel cell carcinoma. These agents, as monotherapies, are associat...
Conclusions: Podoplanin plays an evident role in the development and progression of both benign and malignant skin neoplasms and may serve as a potential predictor of their clinical course and prognosis.
In this study, we generated iPSCs derived from fibroblasts of four patients with Gorlin syndrome (Gln-iPSCs) with heterozygous mutations of the PTCH1 gene. Gln-iPSCs from the four patients developed into medulloblastoma, a manifestation of Gorlin syndrome, in 100% (four out of four), of teratomas after implantation into immunodeficient mice, but none (0/584) of the other iPSC-teratomas did so. One of the medulloblastomas showed loss of heterozygosity in the PTCH1 gene while the benign teratoma, i.e. the non-medulloblastoma portion, did not, indicating a close clinical correlation between tumorigenesis in Gorlin syndrome pa...