A Primer on Extramammary Paget's Disease for the Urologist A Primer on Extramammary Paget's Disease for the Urologist
Find out what urologists need to know about the diagnosis and management of extramammary Paget's disease.Translational Andrology and Urology
Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Elizabeth Stephens, Michèle Roy, Martine Bisson, Hoang Dong Nguyen, Michelle S. Scott, Gilles Boire, Luigi Bouchard, Sophie Roux
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Daniel Leff, Paul Thiruchelvam, Neill Patani, Ruth Robinson, James Paget, Aadil Khan, Susan Cleator, Dorothy Gujral, Anna Kirby, Navita Somaiah, Jennifer Rusby, Simon Wood, Fiona MacNeill, Dimitri Hadjiminas
Definitive treatment of Paget-Schroetter syndrome (PSS) involves first rib resection (FRR),division of the anterior scalene muscle, and resection of the subclavius muscle. This is a single institution experience with PSS, according to a treatment algorithm of preoperative venogram (accompanied by lysis and percutaneous mechanical thrombectomy as needed) followed by transaxillary FRR. In the later period of this experience, patients have often been discharged on aspirin only, with no plan for anticoagulation postoperatively.
Publication date: Available online 20 May 2020Source: Journal of Vascular Surgery: Venous and Lymphatic DisordersAuthor(s): Daniel Silverberg, Michal Fish, Aharon Lubetsky, Uri Rimon, Daniel Raskin, George Greenberg, Moshe Halak
CONCLUSIONS: In an early cohort of outpatient kidney transplant recipients with known or suspected coronavirus disease 2019, many had symptomatic resolution without requiring hospitalization. PMID: 32423908 [PubMed - as supplied by publisher]
The Sustainable Development Goals (SDGs) are a set of goals that aspire to 'leave no one behind', adopted by all members of the United Nations and to be achieved by 2030. Now, four years after the SDGs entered into force, we examine the progress towards th...
LL37 is an autoantigen derived from keratinocytes that can bind to surface scavenger receptors expressed on myeloid dendritic cells (DCs), plasmacytoid DCs, and macrophages to recognize extracellular self-DNA . Among such scavenger receptors, CD163 is a specific surface marker of macrophages . The expression of LL37 on myeloid cells in the dermis is controlled by proinflammatory cytokines such as IL-17 and TNF- α . Since Paget’s cells produce CCL20 and recruit Th17 in the lesional skin of EMPD , the expression of LL37 in invasive EMPD might be increased after the dermal invasion of Paget’s cells.
DiscussionOFAMTX5% represents an alternative skin-directed, painless, patient-friendly and efficacious adjuvant treatment for superficial metastatic lesions of breast cancer. Larger series are required to evaluate the potential of OFAMTX5% for the treatment of superficial metastatic lesions of breast cancer.
We report a case of recurrence as Paget's disease at the core needle biopsy (CNB) entry site in a patient with microinvasive ductal carcinoma who underwent nipple-areola-skin sparing mastectomy (NASSM) and autologous reconstruction. Clinically diagnosed recurrences associated with previous needle procedures for malignant breast lesions are rare and usually occur in patients who have not received radiation therapy. The present case involved local recurrence at the skin puncture site of a patient diagnosed based on CNB findings who underwent NASSM without receiving radiation therapy. Although the removal of the CNB tract wit...