A Peculiar Phenotype Hindering Early Diagnosis: Multiple Endocrine Neoplasia 2B Syndrome

A 28-year-old Chinese man presented to the emergency department (ED) with acute onset of abdominal distension, generalized abdominal pain, and repeated vomiting. There was no fever, diarrhea, or gastrointestinal bleeding. He reported chronic constipation requiring ED attendance five years ago due to abdominal distension and nausea, but his bowel habit had not changed recently.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Diagnostic Dilemma Source Type: research

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In a recent [1] retrospective analysis in 325 non-valvular atrial fibrillation (NVAF) patients treated with novel oral anticoagulants (NOAC), authors suggested a higher risk of thrombosis in obese/overweight vs. other patients, particularly those treated with dabigatran; and a higher risk of bleeding, particularly related to factor Xa inhibitors (rivaroxaban, apixaban). They proposed that obesity moderated the NOAC effects, differently for different NOACs. However a) the study did not test for moderation [(warfarin vs.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the editor Source Type: research
Objectives: A previous pilot study demonstrated that various fixed-dose combinations (FDCs) of ibuprofen (IBU) and acetaminophen (APAP) provided analgesic efficacy comparable to a higher dose of IBU, with the same safety profile. These studies further evaluated the chosen FDC IBU/APAP 250/500 mg formulation. Materials and Methods: Two phase 3 dental pain studies enrolled healthy young patients with ≥moderate pain after ≥3 third molar extractions who received single-dose FDC IBU/APAP 250/500 mg, IBU 250 mg, APAP 650 mg, or placebo evaluated over 12 hours (study 1) or multiple-dose FDC ...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Recovery is a multidimensional and complex construct. In addition to pain intensity and disability, measurement and conceptualization of recovery should focus on emotional well-being, self-perception, and the cultural values and beliefs of the individual. A positive therapeutic relationship, with attention to psychological and social influences, appears to be important in facilitating recovery and well-being.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS. Materials and Methods: All patients were diagnosed with hyperalgesia associated with CRPS. Patients underwent an outpatient, 4-day, escalating dose ketamine infusion. Hyperalgesia was measured using pain thresholds. Clinical outcome was determined without knowledge of the patient’s pain thresholds throughout treatment. Results: We ...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: The current study confirmed that individuals preparing a movement attended more toward somatosensory stimuli at the lower back when anticipating back pain during the movement, as measured by the N96 SEP. However, no differences were found between participants with chronic low back pain or recurrent low back pain, or the pain-free controls.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: A significant difference in therapy effect, favoring acupuncture, was found for pain at
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Participants were knowledgeable regarding chronic pain, but still indicated that receiving a definite diagnosis would be the most helpful intervention. Most had tried multiple interventions and did not believe that further medication, testing, or surgery would solve their pain. Instead, parents presenting at this Functional Abdominal Pain Program appeared most hopeful about the benefits of multidisciplinary treatment approaches including psychological interventions, a focus on activity and functioning, and complementary and alternative medicine interventions.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Objectives: Adductor canal block (ACB) could provide effective postoperative pain control for patients after total knee arthroplasty (TKA). However, some authors pointed out that the ACB as originally described may be more similar to a femoral triangle block (FTB). Recent neuroanatomic evidences made the authors conjecture that the “true” ACB would provide superior analgesia compared with FTB. Therefore, the study was designed to determine the hypothesis that postoperative analgesia after TKA could be improved by a “true” ACB compared with FTB. Materials and Methods: Patients undergoing unilate...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Normal levels of pressure pain tolerance at baseline predicted greater improvement in clinical pain severity after EAET than CBT. Quantitative sensory testing may provide insights about individual responses to psychologically based therapies for individuals with chronic pain.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
No abstract available
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Letter to the Editor Source Type: research
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