Anal Melanoma: A Rare Perianal Tumor With a Poor Prognosis

Case Summary: A 69-year-old woman with a nonrelevant past medical history was referred to an outpatient colorectal clinic because of the incidental finding of an anal pigmented lesion during a routine gynecological examination. Anal inspection and proctoscopy indicated possible anal melanoma (Fig. 1A and B).
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Resident’s Corner Source Type: research

Related Links:

Contributors : Anuhar Chaturvedi ; Razif Gabdoulline ; Michael HeuserSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene expression, and thus may promote tumorigenesis. Data for IDH1 inhibitors show that 30-40% of AML patients respond to monotherapy with a median duration of response of 8 mont...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Anuhar Chaturvedi ; Razif Gabdoulline ; Michael HeuserSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensMutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene expression, and thus may promote tumorigenesis. Data for IDH1 inhibitors show that 30-40% of AML patients respond to monotherapy with a median duration of response of 8 months, su...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
Publication date: Available online 24 May 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Adrián Varela-Vázquez, Amanda Guitián-Caamaño, Paula Carpintero-Fernandez, Eduardo Fonseca, Samar Sayedyahossein, Trond Aasen, Silvia Penuela, María D. Mayán
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsPET/CT can detect metastatic melanoma lesions over about 2  cm in size, with hot lesions generally visible at smaller sizes.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Cutaneous malignant melanoma continues to be a significant public health challenge in the United Kingdom, with an incidence rate of 25.9 per 100 000 population and an increase of 38% in age standardised incidence over the last decade.1
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research
Abstract Cutaneous metastases (CMs) signal the spread of a primary tumor to the skin and dermis, particularly in patients with melanoma or with breast, lung, or gastrointestinal cancers. Although these lesions may present as superficial and painless, some CMs may lead to ulceration, drainage, and discomfort, causing distress to patients. Oncology nurses require knowledge about the clinical presentation of CMs, including incidence, pathophysiology, diagnostic evaluation, and complex symptomatology, as well as standard treatment and care for patients. In addition, nurses can provide psychosocial interventions to ass...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin J Oncol Nurs Source Type: research
Publication date: Available online 22 May 2020Source: Seminars in Cancer BiologyAuthor(s): Prisca Bustamante, Léo Piquet, Solange Landreville, Julia V. Burnier
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
This article reviews the indications, efficacy, safety profile and evidence supporting checkpoint inhibition as therapeutics for metastatic melanoma, cutaneous squamous cell carcinoma, and Merkel cell carcinoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
AbstractSkin cancers remain the most common group of cancers globally, and the incidence continues to rise. Although localized skin cancers tend to have excellent outcomes following surgical excisions, the less common cases that become surgically unresectable or metastatic have been associated with poor prognosis and suboptimal treatment responses to cytotoxic chemotherapy. Development of monoclonal antibodies to programmed cell death-1 receptor and its ligand (PD-1/PD-L1) have transformed the management of metastatic melanoma, squamous cell carcinoma, and Merkel cell carcinoma. These agents, as monotherapies, are associat...
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 May 2020Source: Sensing and Bio-Sensing ResearchAuthor(s): Naricha Pupinyo, Arto Heiskanen, Orawon Chailapakul, Lo Gorton, Jenny Emnéus, Wanida Laiwattanapaisal
Source: Sensing and Bio Sensing Research - Category: Research Source Type: research
More News: Gastroenterology | Melanoma | Skin Cancer