Circulating endothelial cell-derived microvesicles are elevated with hypertension and associated with endothelial dysfunction.

CIRCULATING ENDOTHELIAL CELL-DERIVED MICROVESICLES ARE ELEVATED WITH HYPERTENSION AND ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION. Can J Physiol Pharmacol. 2020 Apr 08;: Authors: Stockelman KA, Hijmans JG, Bammert T, Greiner JJ, Stauffer BL, DeSouza C Abstract The purpose of this study was to determine: 1) if circulating endothelial microvesicles (EMVs) are elevated in hypertensive adults; and 2) whether circulating EMVs are associated with hypertension-related endothelial vasodilator dysfunction. Circulating EMVs (CD31+/42b-) was determined in 30 middle-aged adults (55+1 years): 15 normotensive (10M/5F; BP: 114/71+2/1 mmHg) and 15 hypertensive (10M/5F; 142/87+2/2 mmHg). Forearm blood flow (FBF: via plethysmography) was assessed by intra-arterial infusion of acetylcholine and sodium nitroprusside. Circulating EMVs were ~65% higher (P<0.05) in hypertensive (157±10 EMV/µL) than normotensive (96±10 EMV/µL) adults. FBF to acetylcholine was significantly lower (~30%) in the hypertensive (from 5.0 ± 0.4 to 11.8 ± 0.8 mL/100 mL tissue/min vs 4.4 ± 0.2 to 15.6 ± 0.8 mL/100 mL tissue/min) group. Circulating EMVs were inversely associated with vasodilation (r=-0.65; p<0.05). Hypertension is associated with elevated circulating levels of EMVs. EMVs may serve as a biomarker of, and contribute to, blood pressure-related endothelial dysfunction. PMID: 32268071 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research