Construction of atomic models of full hepatitis B vaccine particles at different stages of maturation

Publication date: Available online 9 April 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Laurent Berthier, Olivier Brass, Gilbert Deleage, Raphaël Terreux
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research

Related Links:

Previously, a telomerase-derived 16-mer peptide, GV1001, developed as an anticancer vaccine, was reported to exert antiviral effects on human immunodeficiency virus or hepatitis C virus in a heat shock protein-dependent manner. Here we investigated whether GV1001 exerts antiviral effects on hepatitis B virus (HBV) and elucidated its underlying mechanisms. GV1001 inhibited HBV replication and hepatitis B surface antigen (HBsAg) secretion in a dose-dependent manner, showing synergistic antiviral effects with nucleos(t)ide analogs (NAs) including entecavir and lamivudine. This peptide also inhibited viral cccDNA and pgRNA. Th...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Abstract The addition of aluminum-based adjuvants in vaccines enhances the immune response to antigens. The strength of antigen adsorption on adjuvant gels is known to modulate vaccine efficacy. However, a detailed understanding of the mechanisms of interaction between Al- gels and antigens is still missing. Here, we implement a new analytical approach based on Dynamic Nuclear Polarization (DNP) enhanced NMR spectroscopy under Magic Angle Spinning (MAS) to provide a molecular description of antigen-adjuvant interface. This approach is demonstrated on Hepatitis B surface antigen (HBsAg) particles in combination wit...
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research
Discussion “Tattooing of skin via deposition of pigment particles and ink ingredients in the dermis changes normal skin into abnormal skin. Fortunately, this often causes no harm and no disease, although with important exceptions.” Tattoos can be inadvertent from road dirt, gunpowder, pencil graphite etc., but most are desired. Tattoos are common in many cultures and over time..They have been increasing in popularity in the United States over the past few years particularly with a younger, wider and more diverse population. Newsweek reported an 18-country study in 2018 which showed 46% of Americans have a tat...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 16 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Mei Ji, Jie Zhu, Xi-xiu Xie, Dong-qun Liu, Bin Wang, Zhuo Yu, Rui-tian Liu
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Fewer children are getting vaccinated in the Democratic Republic of the Congo (DRC) and the COVID-19 pandemic is almost certainly going to make matters worse, the United Nations Children’s Fund (UNICEF) says. If the trend continues, it could trigger a resurgence in deadly childhood diseases such as polio, chickenpox, measles, yellow fever, hepatitis B, diphtheria, tetanus, whooping cough and meningitis.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
We describe 2 preterm neonates with transient hepatitis B surface (HBs) antigenemia detected after Hepatitis B vaccination. Repeat serology in both cases tested negative for hepatitis B surface antigen, confirming transient HBs antigenemia. The duration of transient HBs antigenemia affirms current literature in the pediatric population.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research
Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Abstract Hepatitis B and hepatitis C (HCV) prevalence are higher in people on hemodialysis (HD) than the general population. Through implementation of prevention interventions including vaccines, serologic screening, and post-exposure management, transmissions linked to HD have decreased dramatically. In this manuscript, we review epidemiology of viral hepatitis, summarize current screening and vaccine recommendations, and appraise the available data about efforts to decrease incidence within HD facilities, including isolation of people with viral hepatitis within HD units. Also included is a discussion of the hig...
Source: Seminars in Dialysis - Category: Urology & Nephrology Authors: Tags: Semin Dial Source Type: research
AbstractPurposeTo determine serum 25(OH)D and 1,25(OH)2D relationship with hepatitis B vaccination (study 1). Then, to investigate the effects on hepatitis B vaccination of achieving vitamin D sufficiency (serum 25(OH)D  ≥ 50 nmol/L) by a unique comparison of simulated sunlight and oral vitamin D3 supplementation in wintertime (study 2).MethodsStudy 1 involved 447 adults. In study 2, 3  days after the initial hepatitis B vaccination, 119 men received either placebo, simulated sunlight (1.3 × standard-erythema dose, 3 × /week for 4 weeks and then 1&thin...
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
More News: Hepatitis | Hepatitis B | Hepatitis Vaccine | Molecular Biology | Vaccines