Scientists Scan for Weaknesses in the SARS-CoV-2 Spike Protein

The virus's tool for prying open host cells is coated in a protective armor of sugar--but gaps may offer vulnerability to disruption by antibodies.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news

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Conditions:   Covid-19;   Anosmia Intervention:   Other: Brain MRI scan Sponsor:   Centre Hospitalier Universitaire de Nīmes Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report a 63-year-old Wuhan male patient with smoking history of 40 cigarettes per day for 40 years. He sought medical consultation for right lower lung nodules found by CT scan. Diagnoses and interventions: The patient's postoperative pathological diagnosis was squamous cell carcinoma of the right lower lung. On the fourth day after the operation, the real-time reverse transcription polymerase chain reaction test showed a positive result. After the operation, we routinely give symptomatic treatments such as anti-infection, nebulization and oxygen inhalation. We also change antibiotics several times depending on the p...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
While things appear to be slowly opening up again in many parts of the world, many people continue to feel hesitant to leave their homes, fearful of exposure to COVID-19. The resulting sense of isolation, depression, and anxiety are keeping mental health hotlines busy. Without sounding too rosy, is there the possibility of extracting something positive from the turn inward that circumstances are now offering? A telephone survey of 818 Hong Kong residents of age 18-60 during the SARS epidemic in 2003 offers glimmers of hope.  Researchers have reported in the Journal of Infection (August, 2006) that over 60% of respond...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Depression Friends Happiness Inspiration & Hope Mindfulness Psychology Relationships Self-Help Friendship Optimism social distancing Social Isolation Source Type: blogs
By MICHEL ACCAD Last month marked the 400th anniversary of the birth of John Graunt, commonly regarded as the father of epidemiology.  His major published work, Natural and Political Observations Made upon the Bills of Mortality, called attention to the death statistics published weekly in London beginning in the late 16th century.  Graunt was skeptical of how causes of death were ascribed, especially in times of plagues.  Evidently, 400 years of scientific advances have done little to lessen his doubts!  A few days ago, Fox News reported that Colorado governor Jared Polis ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Medical Practice Physicians Diagnosis MICHEL ACCAD Source Type: blogs
The COVID-19 pandemic has had significant global consequences, with healthcare systems stretched to their limits, a growing death toll, and economic devastation as economies came grinding to a halt. The pandemic and its aftereffects will be with u...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Medicine Public Health Source Type: blogs
Publication date: June 2020Source: Journal of Hospital Infection, Volume 105, Issue 2Author(s): J.A. Al-Tawfiq, Z.A. Memish
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionsThe [18F]FDG-PET/CT can identify probable Covid-19 disease in the absence or before symptoms onset and can guide patient management. Nuclear medicine staff needs to be aware of the possibility of contact with patients affected by the SARS-CoV-2 infection even if they do not present any symptom. Therefore, safety measures need to be adopted for other patients and hospital staff in order to block the spread of infection.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
The novel coronavirus SARS-CoV2 emerged in December 2019 and is now pandemic. Initial analysis suggests that 5% of infected patients will require critical care, and that respiratory failure requiring intubatio...
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - Category: Emergency Medicine Authors: Tags: Guideline Source Type: research
Authors: Pesaresi M, Pirani F, Tagliabracci A, Valsecchi M, Procopio AD, Busardò FP, Graciotti L Abstract From two COVID-19-related deaths, samples of lung, heart and kidney were collected and processed for Transmission and Scanning Electron Microscopy (TEM and SEM) with the aim of identifying the virus. Virions of SARS-CoV-2 were found in all tissues by TEM and SEM, corroborating the hypothesis that the virus enters the cells of different organs. This is the first report identifying SARS-CoV-2 in different human tissues by TEM and SEM. PMID: 32432787 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ConclusionsMost of the pregnant COVID ‐19 positive patients had a favorable clinical course. However, one‐third of them developed pneumonia, of whom 5% presented a critical clinical status. CRP and D‐dimer levels positively correlated with severe pneumonia and the neutrophil/lymphocyte ratio decreased as the patients improved clin ically. Seventy‐eight percent of patients had a vaginal delivery. No vertical or horizontal transmissions were diagnosed in the neonates during labor or breastfeeding.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
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