Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer ’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain

Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in organs and tissues, and has been shown to be involved in synaptic plasticity and neuroprotection in mammalian brain. Calpain-1 deletion results in a number of phenotypic alterations. While some of these alterations can be explained by the acute functions of calpain-1, the present study was directed at studying alterations in gene expression that could also account for these phenotypic modifications. RNA-seq analysis identified 354 differentially expressed genes (DEGs) in brain of calpain-1 knock-out mice, as compared to their wild-type strain. Most DEGs were classified in 10 KEGG pathways, with the highest representations in Protein Processing in Endoplasmic Reticulum, MAP kinase and Alzheimer’s disease pathways. Most DEGs were down-regulated and validation of a number of these genes indicated a corresponding decreased expression of their encoded proteins. The results indicate that calpain-1 is involved in the regulation of a significant number of genes affecting multiple brain functions. They also indicate that mutations in calpain-1 are likely to be involved in a number of brain disorders.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

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Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
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Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
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Source: - Daily MedNews - Category: General Medicine Source Type: news
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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Source: NeuroImage: Clinical - Category: Radiology Source Type: research
American Journal of Psychiatry,Volume 177, Issue 6, Page 476-478, June 01, 2020.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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