Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer ’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain

Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in organs and tissues, and has been shown to be involved in synaptic plasticity and neuroprotection in mammalian brain. Calpain-1 deletion results in a number of phenotypic alterations. While some of these alterations can be explained by the acute functions of calpain-1, the present study was directed at studying alterations in gene expression that could also account for these phenotypic modifications. RNA-seq analysis identified 354 differentially expressed genes (DEGs) in brain of calpain-1 knock-out mice, as compared to their wild-type strain. Most DEGs were classified in 10 KEGG pathways, with the highest representations in Protein Processing in Endoplasmic Reticulum, MAP kinase and Alzheimer’s disease pathways. Most DEGs were down-regulated and validation of a number of these genes indicated a corresponding decreased expression of their encoded proteins. The results indicate that calpain-1 is involved in the regulation of a significant number of genes affecting multiple brain functions. They also indicate that mutations in calpain-1 are likely to be involved in a number of brain disorders.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research

Related Links:

Conclusions: HWE deviation of particular variants in relation to global populational HWE, could be, at least in part, associated with the differential susceptibility of specific populations and ethnicities to neurodegenerative diseases. Our data might contribute to the epidemiology and diagnostic/prognostic methods for neurodegenerative diseases.RESUMO Introdu ção: Mitocôndrias defeituosas ou danificadas resultam em alterações do metabolismo energético, equilíbrio redox e dinâmica celular e são, portanto, identificadas como o ponto central da patogênese em ...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Conclusion: The burden of disease (BD) increased by 1.6% from 1990 to 2015. The main causes were migraine, CVD, and NE. ADD and NSC doubled the DALY in this period. These diseases represent a significant cause of disability attributable to the increase in the life expectancy of our population among other factors. Priority actions should be taken to prevent and treat these causes.RESUMEN Introducci ón: Los indicadores de carga de la enfermedad evalúan el impacto que producen las enfermedades en una población. Integran la mortalidad y discapacidad en un solo indicador. Esto permite fijar prioridades para...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
MONDAY, June 1, 2020 -- Tauvid (flortaucipir F18), a radioactive diagnostic agent, was approved to image tau pathology in patients with cognitive impairment being evaluated for Alzheimer disease, the U.S. Food and Drug Administration announced...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Alpna Tyagi, Carol Mirita, Nadine Taher, Iman Shah, Emily Moeller, Anit Tyagi, Thomas Chong, Subbiah Pugazhenthi
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Jae-Won Jang, Yeshin Kim, Seongheon Kim, Sang Won Park, Sung Ok Kwon, Young Ho Park, Jae-Sung Lim, Young Chul Youn, Sung Hun Kim, SangYun Kim, Alzheimer's Disease Neuroimaging Initiative
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
American Journal of Psychiatry,Volume 177, Issue 6, Page 476-478, June 01, 2020.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research
DEMENTIA symptoms can be difficult to spot in its early stages, although there are a number of warning signs to look out for - including memory loss. These are the five most common early symptoms of Alzheimer's disease. Should you speak to a doctor about your dementia risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 30 May 2020Source: Journal of Neuroscience MethodsAuthor(s): Georgia-Ioanna Kartalou, Thomas Endres, Volkmar Lessmann, Kurt Gottmann
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model. Mol Med Rep. 2020 May 18;: Authors: Cui W, Sun C, Ma Y, Wang S, Wang X, Zhang Y Abstract Cognitive impairment and neuro‑inflammatory responses are the distinctive characteristics of Alzheimer's disease (AD). Tormentic acid (TA) is one of the major active components of Potentilla chinensis and has been demonstrated to have anti‑inflammatory properties. However, the potential effects of TA on neuro‑inflammatory responses and memory impairment in AD remain unknown. ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
More News: Alzheimer's | Brain | Calcium | Genetics | Neurology | Study