Early Experience with COVID-19 in Kidney Transplantation

In this edition of Kidney International, we publish two series of kidney transplant patients during the Covid-19 pandemic, which have taken different approaches to transplant immunosuppressive therapy and anti-viral treatment in the early days of the developing pandemic in the United Kingdom and Italy. The first series of 7 cases of COVID-19 infection in kidney transplant recipients comes from St Georges University Hospital in south London, UK (1) and the second series of 20 cases originates from Spedali Civili University Hospital in Brescia, Italy (2).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: editorial Source Type: research

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CONCLUSION: Lockdown and postponement of non-urgent scheduled urological procedures decisions has led to a drastic decrease in surgical activity in AP-HP. Isolated kidney transplantation has been stopped (national statement). Urologists must anticipate for lockdown exit in order to catch-up delayed surgeries. LEVEL OF EVIDENCE: 3. PMID: 32430140 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
While most people are familiar with the hallmark symptoms of COVID-19 by now—cough, fever, muscle aches, headaches and difficulty breathing—a new crop of medical conditions are emerging from the more than 4 million confirmed cases of the disease around the world. These include skin rashes, diarrhea, kidney abnormalities and potentially life-threatening blood clots. It’s not unusual for viruses to directly infect and affect different tissues and organs in the body, but it is a bit unusual for a primarily respiratory virus like SARS-CoV-2, which is responsible for COVID-19, to have such a wide-ranging reach...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract The coronavirus outbreak is a rapidly evolving pandemic, placing unprecedented strain on health-care systems. COVID-19 presents challenges for management of children with renal diseases especially those receiving long-term immunosuppressive medications, including renal transplant recipients and those with chronic kidney disease and acute kidney injury requiring dialysis. Our preparedness for managing this vulnerable group of children is the need of the hour. The purpose of this article is to provide guidance to caregivers and health care personnel involved in management of children with renal diseases an...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
Nature Reviews Nephrology, Published online: 14 May 2020; doi:10.1038/s41581-020-0305-6The coronavirus disease 2019 (COVID-19) pandemic poses important challenges to the care of patients with immune-mediated kidney diseases and to kidney transplant recipients. Here, we discuss the management of immunosuppression for these patients during the pandemic and suggest potential approaches that could be considered in the absence of validated strategies.
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Source Type: research
(University of Pennsylvania School of Medicine) France and the United States have experienced a tremendous reduction in the number of organ donations and solid organ (kidney, liver, heart, and lung) transplant procedures since the onset of the COVID-19 pandemic. By early April, transplant centers in both countries were conducting far fewer deceased donor transplants compared to just one month earlier, with the number of procedures dropping by 91% in France and 50% in the United States.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-se...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
To The Editor: The COVID-19 pandemic has altered medical practice in all disciplines and subspecialties. In nephrology, such alterations involve the following issues: the availability of staff and resources to perform dialysis in patients with suspected or confirmed COVID; infection-prevention practices, especially in the realm of social isolation; delay in the placement of dialysis vascular accesses and peritoneal dialysis catheter; and continued access to care for patients with established chronic kidney disease (CKD) and immunosuppressed patients with renal transplants.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letter to the editor Source Type: research
The COVID19 pandemic has challenged the resilience of healthcare systems worldwide. Governments have ordered nationwide “lockdowns” (often suddenly) in an attempt to contain the spread of infection. Such measures have posed unexpected challenges to patients with pre-existing diseases, especially in limited resource settings. In the current report, we describe the unique hardships confronted by maintenance in-cent er hemodialysis patients and kidney transplant recipients in India during the current lockdown period.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: letters to the editor Source Type: research
As the coronavirus overwhelms the health care system, people with other illnesses struggle to find treatment.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Transplants Kidneys Tests (Medical) Coronavirus (2019-nCoV) Breast Cancer Rationing and Allocation of Resources Brain Cancer Organ Donation American Cancer Society your-feed-healthcare Source Type: news
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