microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A.
This study aims to investigate the effect of miR-331-3p in rats following SCI. Microarray assay was performed in SCI- and sham-operated rats to evaluate the expression of miR-331-3p. Assigned SCI rats were treated with miR-331-3p agomiR alone or miR-331-3p agomiR plus RAP1A-expressing lentivirus or control agomiR. Rat locomotor performance was evaluated by BBB locomotor rating scale. Neuronal tissue damage and apoptosis were detected by histological analyses and Western blot. Inflammation in spinal cord was determined by detection of the expression of inflammatory genes with qRT-PCR, and ELISA. Downstream expression of RAP1A was measured by Western blot. The results showed that SCI induced the downregulation of miR-331-3p in the spinal cord of SCI rats. Overexpression of miR-331-3p improved the locomotor performance, reduced tissue damage, neuronal apoptosis and inflammation in rat SCI model. Rap1a (Ras-related protein Rap-1A) was predicted as a downstream target for miR-331-3p, and upregulation of RAP1A impaired the beneficial effect of miR-331-3p post- SCI, which was shown as worse locomotor activity, more severe tissue damage, as well as promoting apoptosis and inflammation in SCI rats. Furthermore, miR-331-3p reduced the activation of RAP1A downstream genes via inhibiting RAP1A expression. These findings indicate a protective role of miR- 331-3p in the development of SCI via the modulation of RAP1A, and may help to develop novel therapy against SCI-induced complications. ...
Conclusions Changes in several measures of shoulder pain and function occurred after the home exercise program intervention, although the magnitude of changes was only significantly greater than those of the education-only control condition group for two measures. Significant changes in supraspinatus pathology were not detected with quantitative ultrasound metrics.
This article reviews selected treatment strategies for SCI-associated neuropathic pain.
ConclusionThese results suggest an interplay between lower body scheme distorsions and pain in patients with spinal cord injury.
Journal of Neurotrauma, Ahead of Print.
Conclusions: This pilot study demonstrated that a wheelchair back, which supports the seated spinal curves improves upright posture, functional reach, and wheelchair propulsion skills. Further research is necessary to demonstrate statistical findings as well as to assess back height and lateral support. PMID: 32406808 [PubMed - as supplied by publisher]
Conclusion/clinical relevance: Long-term radial extracorporeal shock wave therapy offers a promising therapeutic alternative for neurogenic heterotopic ossification. PMID: 32397914 [PubMed - as supplied by publisher]
What does physical pain have to do with depression, and vice versa? On today’s Psych Central Podcast, our guest, Dr. Jack Stern, a board-certified neurosurgeon specializing in spinal surgery, explains the psychology of pain and how the two are inextricably linked. Dr. Stern describes how pain can lead to depression and how depression can intensify physical pain. We also find out why opioids don’t work for chronic pain, and how past pain affects current pain. Join us for an in-depth discussion on physical pain and mental health. SUBSCRIBE &REVIEW Guest information for ‘Dr. Jack Stern- Chronic Pain&r...
Conditions: Neuropathic Pain; Spinal Cord Injury Intervention: Other: Neurofeedback Sponsors: Kessler Foundation; University of Surrey Not yet recruiting
Abstract Neuropathic pain is a chronic condition which significantly reduces the quality of life and serious clinical issue that is in general resistant to available therapies. Therefore looking for new analgesics is still critical issue. Recent, studies have indicated that chemokine signaling pathways are crucial for the development of neuropathy; however, the role of CC chemokine receptor 4 (CCR4) in this process has not yet been studied. Therefore, the aim of our research was to investigate the influence of C021 (a CCR4 antagonist) and CCR4 CC chemokine ligands 17 and 22 (CCL17 and CCL22) on the development of ...
Authors: Michel F, Negre T, Baboudjian M, Al-Balushi K, Oliva J, Gondran-Tellier B, Sichez PC, Delaporte V, Gaillet S, Aikiki A, Faure A, Karsenty G, Lechevallier E, Boissier R Abstract OBJECTIVE: To report the effectiveness, reliability and learning curve of Microperc, a minimal invasive percutaneous technique using a 4.85-Ch (16-gauge) sheath, in the treatment of nephrolithiasis. MATERIAL AND METHODS: 31 consecutive Micropercs for nephrolithiasis