Altered metabolism in pulmonary hypertension: fuelling the fire or just smoke?

Pulmonary arterial hypertension (PAH) is characterised by progressive obliteration of the pulmonary vasculature, culminating in right-sided heart failure (HF). In recent years, studies have observed an association between systemic metabolic dysfunction, PAH and right ventricular failure [1]. Patients with PAH have an increased prevalence of obesity [2] and type 2 diabetes [3, 4]. Interestingly, abnormal glucose metabolism is evident even in non-diabetic individuals with PAH [5–7], and serves as an independent predictor of prognosis [8].

Source: European Respiratory Journal - April 8, 2020 Category: Respiratory Medicine Authors: Duan, D., Gu, C., Jun, J. C. Tags: Editorials Source Type: research