Curative D2 vs D1 Lymphadenectomy in Operable Gastric Carcinoma
Condition: Gastric Cancer Interventions: Procedure: D1 lymphadenectomy; Procedure: D2 lymphadenectomy Sponsor: University of Alexandria Completed
kavous Parang We have previously reported cyclic cell-penetrating peptides [WR]5 and [WR]4 as molecular transporters. To optimize further the utility of our developed peptides for targeted therapy in cancer cells using the redox condition, we designed a new generation of peptides and evaluated their cytotoxicity as well as uptake behavior against different cancer cell lines. Thus, cyclic [C(WR)xC] and linear counterparts (C(WR)xC), where x = 4–5, were synthesized using Fmoc/tBu solid-phase peptide synthesis, purified, and characterized. The compounds did not show any significant cytotoxicity (at 25 µ...
In the Netherlands, neoadjuvant chemoradiotherapy (nCRT) has become standard treatment for non-metastic resectable esophageal cancer as it increases survival compared to surgery alone. Stenosis of the cervical anastomosis is a common postoperative complication after gastric tube reconstruction requiring endoscopic dilations. We hypothesized that radiation dose on the future anastomotic region (FAR) was related to the occurrence and severity of the anastomotic stenosis. We evaluated the incidence of stenosis and analyzed risk factors associated with severity of the stenosis.
With the advancement in endoscopic equipment, superficial carcinoma of the esophagogastric junction is more frequently detected and more likely to be treated with endoscopic treatment in recent years than in previous years in Japan. However, it is difficult to diagnose the lateral extension of esophagogastric cancer when these lesions extend under the squamous epithelium. Although cancer under the squamous epithelium (CUS) of Barrett's esophageal cancer (BC) is well-known, the CUS of gastric cardiac cancer (GC) remains largely unclear.
Gastric adenomas are neoplastic with similar microscopic findings to those seen in colonic adenomas. Around 8-59% of gastric adenomas are associated with synchronous gastric carcinoma and hence repeat upper endoscopic surveillance after one year is usually recommended. On the other hand, the data has been scarce and inconsistent with regards to their association with colonic polyps and colorectal cancer. We aimed to analyze the previously published literature evaluating the association between gastric neoplasm and colonic polyps and colorectal cancer.
Epstein-Barr Virus (EBV)-associated gastric cancer (EBVGC) accounts for approximately 10% of gastric cancers. EBVGC is classified into one of the four molecular subtypes proposed by The Cancer Genome Atlas Research Network (Nature, 2014), and there have been reports which imply the relatively low risk of lymph node metastasis (LNM) in EBVGC with submucosal invasion (pT1b-EBVGC). However, a large cohort study is still lacking.
ConclusionsConsuming fresh fruit more than 12 times/year may reduce the long ‐term risk of ESCC mortality in this dysplasia population, particularly in females, non‐smokers, and nondrinkers. Future studies are needed to confirm these findings.
ConclusionsWhile several CPGs are shared across patients, many pathogenic variants are found to be ancestry-specific and trigger somatic effects. Studies using larger cohorts of diverse ancestries are required to pinpoint ancestry-specific genetic predisposition and inform genetic screening strategies.
Authors: Wu M, Jiang M, Dong T, Xu L, Lv J, Xue M, Huang M Abstract BACKGROUND: One of the most common treatment for gastric cancer is chemotherapy, however, multiple drug resistance (MDR) induce the therapeutic effect which result in the failure of anticancer therapy. Dihydromyricetin (DMY) was reported to have antitumor activities on various human cancer cells in vitro, our previous studies demonstrated that DMY combined with mitomycin has inhibitory effect on proliferation of gastric carcinoma cells. However, the underlying role of DMY reversing the MDR of gastric carcinoma is poor understood. The aim of this st...
Conclusions: In the treatment of intractable carcinomatous pain in patients with retroperitoneal lymph node metastases, CT-guided125 I brachytherapy is a feasible and effective modality for pain palliation.
Our data highlighted that TME ‐related TFs, especially HEYL, may represent a potentially promising target of diagnosis and clinical interventions for gastric cancer patients. AbstractTranscription factors represent the crucial role of controlling gene transcription in cancer development and progression. However, their functions in gastric cancer have not been thoroughly characterized. For this study, we comprehensively evaluated the correlation between infiltration patterns of tumor microenvironment (TME) cells and TFs expression in the cohort of stomach adenocarcinoma (STAD) from TCGA database. We integrally explored di...