Age at menopause, body mass index, and risk of type 2 diabetes mellitus in postmenopausal Chinese women: The Henan Rural Cohort Study

Publication date: Available online 8 April 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Lulu Zhang, Lei Bao, Yuqian Li, Chongjian Wang, Xiaokang Dong, Tanko Abdulai, Xiu Yang, Mengying Fan, Songyang Cui, Wen Zhou, Zhenxing Mao, Wenqian Huo, Dandan Wei, Linlin Li
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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Conclusions: Late menarche may be negatively associated with T2DM. The potential mechanism is adiposity and IR completely mediating the association between age at menarche and T2DM.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Objective: To determine the effect of metformin on marrow adiposity in postmenopausal women with newly diagnosed type 2 diabetes mellitus (T2DM). Methods: We enrolled 25 postmenopausal T2DM women who satisfied the requirement of having been on 1 year of metformin therapy and 26 age-matched healthy women receiving a placebo. All participants were analyzed for marrow fat fraction (FF) by magnetic resonance spectroscopy, vertebral volumetric bone mineral density (vBMD) by quantitative computed tomography, blood glucose, lipid profiles, and bone biomarkers to compare values before and after the interventions. Differences ...
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Abstract PURPOSE: The aims of this study were to evaluate the effect of age at menarche (AM) on type 2 diabetes mellitus (T2DM) and to assess whether the fasting plasma glucose (FPG) and homeostasis model assessment (HOMA) index responses to AM and menopause status interact in Chinese rural adults. METHODS: A cross-sectional, population-based study including 23138 participants was performed. Logistic regression and multivariable linear regression were performed to investigate the relationship between AM and glucose status. Generalized linear model was utilized to calculate the interaction term of AM and menop...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
AbstractDuring menopausal transition, various phenotypical and metabolic changes occur, affecting body weight, adipose tissue distribution and energy expenditure as well as insulin secretion and sensitivity. Taken together, these can predispose women to the development of type 2 diabetes mellitus (T2DM). Many women in midlife experience climacteric symptoms, including hot flashes and night sweats. Menopausal hormone therapy (MHT) is then indicated. MHT has a favourable effect on glucose homeostasis in both women without and with T2DM. T2DM was considered in the past as a cardiovascular disease (CVD) equivalen...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
Conclusions: Early menarche increases the risk of T2DM, whereas later menarche decreases the risk. The association seems to be partially mediated by BMI.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
Conclusions: T2DM status moderated the relationship between blood adiponectin and ALMBMI, where blood adiponectin was positively associated with ALMBMI in postmenopausal women without T2DM, but not those with T2DM. Dysregulated metabolism in T2DM may contribute to lower muscle mass in women with T2DM, but future research is required to elucidate this mechanistic link. The negative association between blood leptin and ALMBMI was a novel finding. Future studies will need to more clearly define the relationship between these variables.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
To investigate the prevalence of cardiovascular disease (CVD) risk factors and assess the 10-year risk of CVD in non-menopausal and postmenopausal women with type 2 diabetes mellitus (T2DM).
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research
Objectives: The purpose of this study was to determine the associations between type 2 diabetes mellitus and sleep-related symptoms among midlife women from four major racial/ethnic groups in the United States. Methods: The data from 164 participants of two larger Internet survey studies (62 women diagnosed with type 2 diabetes and 102 women without diabetes) were included. In the original studies, multiple instruments including the questions on background characteristics, health status, and menopause status and the Sleep Index for Midlife Women were used. The data were analyzed using χ2 tests, independent t tests...
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research
AbstractDuring menopausal transition, various phenotypical and metabolic changes occur, affecting body weight, adipose tissue distribution and energy expenditure as well as insulin secretion and sensitivity. Taken together, these can predispose women to the development of type 2 diabetes mellitus (T2DM). Many women in midlife experience climacteric symptoms, including hot flashes and night sweats. Menopausal hormone therapy (MHT) is then indicated. MHT has a favourable effect on glucose homeostasis in both women without and with T2DM. T2DM was considered in the past as a cardiovascular disease (CVD) equivalent, which would...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
WEDNESDAY, Aug. 21, 2019 -- Middle-aged women with type 2 diabetes mellitus (T2DM) have more sleep disturbances than women without diabetes, even when accounting for menopause and other health issues, according to a study published online Aug. 12 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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