GSE148288 A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: the transcription factor CgTog1

Contributors : Pedro Pais ; Susana Vagueiro ; Dalila Mil-Homens ; Andreia I Pimenta ; Romeu Viana ; Michiyo Okamoto ; Hiroji Chibana ; Ars énio M Fialho ; Miguel C TeixeiraSeries Type : Expression profiling by high throughput sequencingOrganism : [Candida] glabrataThe goals of this study are to compare C. glabrata transcriptome profiling (RNA-seq) upon exposure to hydrogen peroxide in order to assess the correspondent response. The role of the transcription factor Tog1 is clarified through comparison of the transcrptome profiles of WT and Tog1 mutant cells. mRNA profiles of WT and ∆tog1 were generated by deep sequencing, in duplicate, using Illumina HiSeq. The sequence reads that passed quality filters were analyzed with TopHat followed by HTSeq. RNA-seq data allowed to identify genes whose expression is regulated by the Tog1 transcription factor (147 positively regulated a nd 112 negatively regulated) with a log2fold change ≥0.5 and p value

Source: GEO: Gene Expression Omnibus - April 9, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing [Candida] glabrata Source Type: research