Metabolic alterations in immune cells associate with progression to type 1 diabetes

Conclusions/interpretationOur data suggest that systemic dysregulation of lipid metabolism, as observed in plasma, may impact the metabolism and function of immune cells during progression to overt type 1 diabetes.Data availabilityThe GEMs for PBMCs have been submitted to BioModels (www.ebi.ac.uk/biomodels/), under accession number MODEL1905270001. The metabolomics datasets and the clinical metadata generated in this study were submitted to MetaboLights (https://www.ebi.ac.uk/metabolights/), under accession number MTBLS1015.
Source: Diabetologia - Category: Endocrinology Source Type: research

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Publication date: Available online 3 June 2020Source: Life SciencesAuthor(s): Wahid Ali Khan, Arshi Malik, Mohd. Wajid Ali Khan
Source: Life Sciences - Category: Biology Source Type: research
The bedrock of type 1 diabetes treatment is insulin therapy, but your lifestyle choices are also a crucial part of your treatment.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Condition:   Type 1 Diabetes Intervention:   Other: Exercise bouts Sponsors:   Region Örebro County;   Örebro University, Sweden Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
DiabetesMine chronicles the journey of America's first commercial airline pilot with type 1 diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Authors: Yahaya TO, Ufuoma SB Abstract Single gene mutations have been implicated in the pathogenesis of a form of diabetes mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there are diverse opinions on the suspect genes and pathophysiology, necessitating the need to review and communicate the genes to raise public awareness. We used the Google search engine to retrieve relevant information from reputable sources such as PubMed and Google Scholar. We identified 14 classified MODY genes as well as three new and unclassified genes linked with MODY. These genes are fundamentally embedde...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas ...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
ConclusionsOur study demonstrates that our adolescents with severe obesity carry a much higher CV risk than adolescents with T1D unless in bad metabolic control. Apart from lower sAGE levels, most of the variables considered to define CV risk were higher in the obese group than in the T1D group. Gender seems to have a significant impact on sAGE levels but not on IMT.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Conclusions/interpretationOur study identifies increased responsiveness to IFN-1 as a feature of both the NOD mouse model of autoimmune diabetes and human established type 1 diabetes. A stimulated IFN-1 gene signature may be a potential biomarker for type 1 diabetes and used to evaluate the effects of therapies targeting this pathway.Data availabilityMouse gene expression data are found in the gene expression omnibus (GEO) repository, accession GSE146452 (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146452). Nanostring count data from the human experiments were deposited in the GEO repository, accession GSE146338 (www.ncb...
Source: Diabetologia - Category: Endocrinology Source Type: research
cobs Type 1 diabetes (T1D) is a chronic health condition resulting from pancreatic beta cell dysfunction and insulin depletion. While automated insulin delivery systems are now available, many people choose to manage insulin delivery manually through insulin pumps or through multiple daily injections. Frequent insulin titrations are needed to adequately manage glucose, however, provider adjustments are typically made every several months. Recent automated decision support systems incorporate artificial intelligence algorithms to deliver personalized recommendations regarding insulin doses and daily behaviors. This pape...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
ConclusionsOur study established a novel footprint-free protocol for efficient transdifferentiation of hepatocytes into IPCs using IVT mRNAs of TGIF2 and 3 pTFs, which paved the way toward a clinical application.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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