Metabolic alterations in immune cells associate with progression to type 1 diabetes

Conclusions/interpretationOur data suggest that systemic dysregulation of lipid metabolism, as observed in plasma, may impact the metabolism and function of immune cells during progression to overt type 1 diabetes.Data availabilityThe GEMs for PBMCs have been submitted to BioModels (www.ebi.ac.uk/biomodels/), under accession number MODEL1905270001. The metabolomics datasets and the clinical metadata generated in this study were submitted to MetaboLights (https://www.ebi.ac.uk/metabolights/), under accession number MTBLS1015.

http://link.springer.com/10.1007/s00125-020-05107-6

Source: Diabetologia - April 9, 2020 Category: Endocrinology Source Type: research