A cross-sectional study of spontaneous repigmentation in vitiligo

Conclusion: Spontaneous repigmentation occurs in one-fifth of patients with vitiligo. In some patients, the repigmentation is clinically significant and long-lasting. Considering its frequency and extent, spontaneous repigmentation should be taken into account both when evaluating novel interventions and counselling patients about the course of the disease.
Source: Indian Journal of Dermatology, Venereology and Leprology - Category: Dermatology Authors: Source Type: research

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Conditions:   Alopecia Areata;   Depressive Episode;   Recurrent Depressive Disorder;   Anxiety Disorders;   Atopic Dermatitis;   Allergic Rhinitis;   Asthma;   Crohn Disease;   Ulcerative Colitis;   Pernicious Anemia;   Type 1 Diabetes;   Hashimoto Thyroiditis;   Graves Disease;   Rheumatoid Arthritis;   Psoriatic Arthritis;   Ankylosing Spondylitis;   Systemic Lupus Erythematosus;   Polymyalgia Rheumatica;   Sjogren's Syndro...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders. Here, the elucidation of key pathogenic factors such as IL-17A/IL-23 on the one hand and IL-4/IL-13 on the other hand profoundly changed our therapeutic practice. The knowledge on intracellular pathways and governing factors is shifting our attention to new druggable molecules. Multiple cytokine receptors signal through Janus kinases (JAKs) and associated signal transducer and activato...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Autoimmune skin diseases are characterized by significant local and systemic inflammation that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway. Advanced understanding of this pathway has led to the development of targeted inhibitors of Janus kinases (JAKinibs). As a class, JAK inhibitors effectively treat a multitude of hematologic and inflammatory diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic dermatitis, alopecia areata, psoriasis, and vitiligo. Additional evidence suggests that JAK inhibition might be broadly useful in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chronic skin diseases have significant impacts on the quality of life (QoL) of the patients, although not life threatening. However, current QoL measurements often do not adequately reflect the actual disease burden of the affected person. Willingness-to-pay (WTP) questionnaire was developed to assess disease burden economically. In this pilot study, we evaluated QoL and WTP in patients with five chronic skin diseases; alopecia areata (AA), atopic dermatitis (AD), chronic urticaria (CU), psoriasis, and vitiligo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune receptors and cytokine receptors, and therefore mediate the recruitment and activation of various leukocyte populations. Non-receptor tyrosine kinases of the Jak, Src, Syk and Btk families play major roles in various immune-mediated disorders, and small-molecule tyrosine kinase inhibitors are emerging novel therapeutics in a number of those diseases. Autoimmune and inflammatory skin diseases represent a broad spectrum of immune-mediated diseases. Genetic and pharmacological studies in humans and mice support the role of tyrosine kinases ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conditions:   Vitiligo;   Psoriasis;   Alopecia Areata;   Atopic Dermatitis Interventions:   Biological: Blood samples;   Biological: Skin biopsies Sponsor:   University Hospital, Bordeaux Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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