Endpoints in Heart Failure Drug Development: History and Future

Publication date: Available online 8 April 2020Source: JACC: Heart FailureAuthor(s): Mona Fiuzat, Naomi Lowy, Norman Stockbridge, Marco Sbolli, Federica Latta, JoAnn Lindenfeld, Eldrin F. Lewis, William T. Abraham, John Teerlink, Mary Walsh, Paul Heidenreich, Biykem Bozkurt, Randall C. Starling, Scott Solomon, G. Michael Felker, Javed Butler, Clyde Yancy, Lynne W. Stevenson, Christopher O'Connor, Ellis Unger
Source: JACC: Heart Failure - Category: Cardiology Source Type: research

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Once considered a rare disease, wild type transthyretin amyloidosis (wtATTR) is currently being recognized as a prevalent disease in the elderly population, as it is estimated to be present in a significant subset of patients with heart failure with preserved ejection fraction (HFpEF) or with degenerative aortic stenosis [1,2]. The increasing population ageing, together with the availability of novel, non-invasive diagnostic tools (namely bone tracer scintigraphy), as well as the growing awareness in the medical community has led to a dramatic increase in the number of diagnosis of wtATTR in the developed countries [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
ConclusionRobotically assisted Heller myotomy and POEM are safe and efficacious treatments for achalasia with lower rates of technical complications compared to laparoscopic Heller myotomy. With the advancements in endoscopic instruments and robotic surgery, POEM and robotically assisted Heller myotomy should be considered in the treatment of achalasia and esophageal dysmotility disorders.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Nocturia impairs quality of life (QoL). We have performed a non-interventional study in which men with lower urinary tract symptoms (LUTS) were treated for at least 3 months with tamsulosin oral controlled absorption system (0.4 mg q.d.). Other than observing efficacy and tolerability of this drug formulation, the study was designed to explore the relative roles of number of nocturia episodes and of non-urological causes of nocturia on nocturia-related QoL at baseline and treatment-associated changes thereof. The study enrolled 5775 men seeking treatment of their LUTS. Tamsulosin improved LUTS, e.g. International Prostate ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractTherapeutic intervention for prostate cancer mostly relies on eliminating circulating androgen or antagonizing its effect at the cellular level. As the use of endocrine therapies grows, an under-reported incidence of cardiovascular toxicities occurs in prostate cancer patients. In this review, we summarize data of clinical studies, investigating the cardiovascular and metabolic alterations associated with the use of old and new endocrine drugs (gonadotropin-releasing hormone [GnRH] agonists and antagonists, androgen receptor inhibitors, 17 α-hydroxylase/c-17,20-lyase [CYP17] inhibitor) in prostate cancer. To ...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Publication date: June 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 6Author(s): Ke LI, Rui ZHANG, Shu-Ying LI, Yue-Tao LIU, Ai-Ping LI, Xiao-Jie LIU, Guan-Hua DU, Xue-Mei QIN
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research
Publication date: Available online 3 June 2020Source: JACC: Heart FailureAuthor(s): Zhejun Cai, Nianguo dong, Fei Li
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Publication date: Available online 3 June 2020Source: JACC: Heart FailureAuthor(s): Ersilia M. DeFilippis, Nosheen Reza, Elena Donald, Michael M. Givertz, JoAnn Lindenfeld, Mariell Jessup
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Authors: Poulin A, Beaupré F, Gravel C, Hadjadj S, Bernier M, Beaudoin J, O'Connor K, Ferreira-Neto AN, Wintzer J, Dumont E, Dagenais F, Rodés-Cabau J, Paradis JM Abstract BACKGROUND: Many patients referred for a MitraClip intervention are finally refused for this intervention, and data are very scarce on their outcomes. Our study sought to determine the characteristics and outcomes of patients who are referred to a mitral valve clinic and are finally denied from a percutaneous mitral edge-to-edge repair. METHODS: A total of 210 patients referred to our clinic for severe mitral regurgitation were ...
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
Evidence strongly suggests that the global faltering of mitochondrial function throughout the body with advancing age has a lot to do with a decline in the effectiveness of mitophagy. Mitochondria are the power plants of the cell, a herd of hundreds swarming and replicating like bacteria in every cell to produce the chemical energy store molecule ATP. Mitophagy is the specialized form of autophagy that destroys worn and damaged mitochondria, recycling their component parts. Without it, cells would become overtaken by broken, malfunctioning mitochondria. Mitochondrial dysfunction leads to too little ATP, but also higher lev...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
This article describes several clinical cases of cardiovascular emergencies, such as coronary stent thrombosis-restenosis, takotsubo syndrome, acute myocarditis, massive pulmonary embolism, type A acute aortic dissection, cardiac tamponade, and endocarditis.
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
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