Oxiconazole Nitrate Solid Lipid Nanoparticles: Formulation, In-vitro Characterization and Clinical Assessment of An Analogous Loaded Carbopol Gel.

Oxiconazole Nitrate Solid Lipid Nanoparticles: Formulation, In-vitro Characterization and Clinical Assessment of An Analogous Loaded Carbopol Gel. Drug Dev Ind Pharm. 2020 Apr 08;:1-26 Authors: Mahmoud RA, Hussein AK, Nasef GA, Mansour HF Abstract The aim of the present work was to develop a promising drug delivery system of oxiconazole nitrate-loaded solid lipid nanoparticles (SLNs) topical gel to enhance the drug effectiveness for the treatment of Tinea infection. SLNs were prepared by emulsification-solvent evaporation method. Particle size and entrapment efficiency of the prepared SLNs were investigated. An appropriate formulation was selected and examined for morphology and physicochemical characterization adopting Scanning electron microscope and Differential scanning colorimetry. In-vitro drug release was also investigated. The selected SLNs were loaded into 1% Carbopol 934 gel that was investigated for homogeneity, pH, grittiness, spreadability, viscosity and in vitro drug release. Clinical study for the developed gel system compared to the corresponding marketed product was conducted on 28 patients. The results revealed that the prepared oxiconazole nitrate SLNs had drug entrapment efficiency ranging from 41.34% to 75.07% and zeta potential lying between -13 and -50. Physicochemical characterization revealed a decrease in the drug crystallinity in the prepared SLNs. The gel formulation showed appropriate physical characteris...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research