Impact of Weight Loss with Laparoscopic Sleeve Gastrectomy on Left Ventricular Diastolic Function: a Prospective Study

AbstractPurposeThe present study purposed to investigate the effects of weight loss with LSG on echocardiographic parameters of diastolic dysfunction in subjects with morbid obesity.MethodsSixty-one subjects undergoing LSG for standard indications were enrolled. All subjects underwent a physical examination, electrocardiography, and transthoracic echocardiography before and 6  months after the LSG. Peak early diastolic velocity (E), deceleration time (DT), and peak late diastolic velocity (A) were measured from the transmitral flow signal. Peak early (e′) diastolic mitral annular velocity was measured at the two acquisition sites (basal septal and basal lateral) using the tissue Doppler recordings.ResultsA significant improvement was observed in echocardiographic measures of the diastolic function includingE/A ratio,E/e′ ratio, DT, and isovolumic relaxation time (IVRT) from baseline to the postoperative 6 months. Left atrial volume index (LAVI) reduced from 30.3 ± 3.9 ml/m2 to 28.0  ± 3.3 ml/m2 (p 
Source: Obesity Surgery - Category: Surgery Source Type: research

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We examined 4 pathologic conditions of IR in humans to examine pathways controlling lipid metabolism and gluconeogenesis.METHODS Cross-sectional study of severe receptor IR (INSR, n = 7) versus postreceptor IR that was severe (lipodystrophy, n = 14), moderate (type 2 diabetes, n = 9), or mild (obesity, n = 8). Lipolysis (glycerol turnover), hepatic glucose production (HGP), gluconeogenesis (deuterium incorporation from body water into glucose), hepatic triglyceride (magnetic resonance spectroscopy), and hepatic fat oxidation (plasma β-hydroxybutyrate) were measured.RESULTS Lipolysis was 2- to 3-fold higher in INSR ver...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Western diet–fed (WD-fed) mice exhibited increased myenteric neuronal pyroptosis, delayed colonic transit, and impaired electric field stimulation–induced colonic relaxation responses. WD incr...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Children who are overweight or obese are at a higher risk of several diseases and are more likely to be overweight or obese in adulthood. Physical inactivity among children and adolescents is one of the major causes of the prevalence of overweight and obes...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 1 June 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Procolo Di Bonito, Lucia Pacifico, Maria Rosaria Licenziati, Claudio Maffeis, Anita Morandi, Melania Manco, Emanuele Miraglia Del Giudice, Anna Di Sessa, Giuseppina Campana, Nicola Moio, Marco Giorgio Baroni, Claudio Chiesa, Giovanni De Simone, Giuliana Valerio, Claudia Forziato, Luisa Gilardini, Sandro Loche, Gianluca Tornese
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conditions:   Covid-19;   Obesity, Childhood;   Lifestyle;   Lifestyle, Healthy;   Overweight, Childhood;   Children, Only;   Family Intervention:   Other: Exposure to the Dutch measures due to the Covid-19 pandemic. Sponsor:   Maastricht University Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Overweight and Obesity;   Emergencies Interventions:   Device: Dynamic ultrasound-guided short-axis needle tip navigation;   Other: Standard technique of placing a PVC Sponsor:   University Hospital, Linkoeping Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obesity Intervention:   Behavioral: Smartphone + Text Messaging with Health Coach Sponsor:   Ohio State University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Bariatric Surgery;   Micronutrient Deficiencies;   Obesity Intervention:   Procedure: Gastric Bypass, Sleeve Gastrectomy Sponsor:   Region Östergötland Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(LONDON) — People in Britain from ethnic minorities have died in larger relative numbers with COVID-19 than their white compatriots, according to a study by British health authorities published Tuesday. But it didn’t answer the biggest question: Why? The Public Health England study found that people of Bangladeshi ethnicity had about twice the risk of death of white Britons. It also found that “accounting for the effect of sex, age, deprivation and region … People of Chinese, Indian, Pakistani, Other Asian, Caribbean and Other Black ethnicity had between 10 and 50% higher risk of death when compare...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 News Desk wire Source Type: news
Study reported the following trends; patients admitted to ICU had baseline comorbidities including hypertension, diabetes, and obesity, were older, predominantly male and had long lengths of stay. Many developed acute kidney injury and some needed dialysis and prolonged intubation.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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