Heart transplant patient brings home the gold

  A rush of excitement swept over Alexia Clinton this past July as she walked into the 22,039 seat Houston Dynamo stadium, hearing her name along with the rest of Team New England called over the loudspeaker. The national youth athletic competition she had waited for all year was about to begin. In addition to winning gold for her softball throw, 10-year-old Alexia won silver in both swimming and long jump and bronze in cornhole. When you consider the fact that she had a heart transplant at the tender age of three, these accomplishments are all the more astonishing. Alexia was participating in the Transplant Games of America, a nationwide sports festival for organ donors and individuals who have had an organ transplant. The games were first held in 1986, with a mission to celebrate and promote organ and tissue donation. State and regional teams compete in events that range from tennis to cycling to ballroom dancing, and age divisions range from “5 and under” to “70 +.”  Alexia was among the event’s most decorated athletes. “I really liked everyone on my team,” she recalls, “and it was nice to see a lot of other kids there, and know I was not the only one who had a transplant.” Not your average stomachache Sandra Clinton, Alexia’s mother, recounts the whirlwind of events that led up to her daughter’s heart transplant. “She had a stomachache, so I took her to her pediatrician. I had no idea how se...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: All posts heart transplant Source Type: news

Related Links:

Abstract Organ transplant from donors with ventricular assist devices is not common. Here, we report organ retrieval from a donor with a left ventricular assist device who had been on the heart transplant wait list before a brain death diagnosis. The organ donor was diagnosed with dilated cardiomyopathy and underwent left ventricular assist device surgery for bridging to heart transplant in 2016. Brain death occurred 22 months after implantation of the device at the age of 39 years due to widespread intraparenchymal and subarachnoid hemorrhage. Brain death diagnosis was confirmed with brain perfusion single-photon...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
Publication date: Available online 5 August 2020Source: The Annals of Thoracic SurgeryAuthor(s): Shahnawaz Amdani, Gerard Boyle, Saarel Elizabeth, Justin Godown, Wei Liu, Sarah Worley, Tara Karamlou
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
We describe the case of an 18‐year‐old male patient, affected by DMD and in a wheelchair from the age of 11. He progressively developed dilated cardiomyopathy, and in 2016, at the age of 14 years, he underwent HeartWare LVAD implantation, as destination therapy, without post‐operative complications. He has been followed up for 47 consecutive months; and 30 months after LVAD implantation, he developed an infection of the exit site, treated by antibiotics and surgical toilette. Following this event, on the basis of patient's good general conditions and willingness, we started to consider heart transplant as a...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
Conclusions: DCM and ICM are considered the most prevalent underlying diseases in heart transplant candidates. Ejection fraction reached normal ranges following transplant, which provides good quality of life. Low incidence of severe acute rejection demonstrates the effectiveness of our immunosuppressive therapy. In the cases of increased rejection, the patient's immunosuppressive regimen was re-assessed accordingly. PMID: 32728361 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
CONCLUSION: Genomic sequencing technologies are valuable for the identification of novel and emerging candidate genes. Biallelic variants in PPP1R13L were previously reported in a single consanguineous family with paediatric DCM. The identification here of a further five families now provides sufficient evidence to support a robust gene-disease association between PPP1R13L and severe paediatric DCM. The PPP1R13L gene should be included in panel-based genetic testing for paediatric DCM. PMID: 32666529 [PubMed - as supplied by publisher]
Source: Clinical Genetics - Category: Genetics & Stem Cells Authors: Tags: Clin Genet Source Type: research
AbstractOwing to shortage of donor hearts, the ventricular assist device is used as a bridging therapy to heart transplantation. However, thrombus formation is a critical complication during ventricular assist device circulatory support that might result in ischemic infarction of end organs. Here, we report a patient diagnosed with decompensated dilated cardiomyopathy and cardiogenic shock who underwent emergent extracorporeal life support, and subsequent temporary bilateral ventricular assistance with the CentriMag device (Levitronix LLC, Waltham, MA). Daily transthoracic echocardiography did not detect any thrombus forma...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
AbstractAimContemporary survival trends in dilated cardiomyopathy (DCM) are largely unknown. The aim of this study is to investigate clinical descriptors, survival trends and the prognostic impact of aetiological characterization in DCM patients.Methods and resultsDilated cardiomyopathy patients were consecutively enrolled and divided into four groups according to the period of enrolment (1978 –1984; 1985–1994; 1995–2004; and 2005–2015). A subset of patients with DCM of specific aetiology, enrolled from 2005 to 2015, was also analysed. Over a mean follow‐up of 12 ± 8 ye...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
CONCLUSIONS: This study has shown that two markers - cardiotropic viruses and myocardial inflammation - are prevalent among DCM patients. They are also helpful in identifying sub-groups of DCM. An increased number of T-lymphocytes in the myocardium is a predictor of poor mid-term and long-term prognosis. PMID: 32567670 [PubMed - as supplied by publisher]
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
In this study we aimed to evaluate management strategies in our pediatric cardiac transplantation candidates with PH and high PVR prior to OHT. METHOD: Twenty-six cardiac transplantation candidates (age: 10.2 ± 4.6, 1-17 years) underwent cardiac catheterization for the determination of PVR and pulmonary arterial pressure. They were admitted to the hospital and received 1-3 days of intravenous (IV) vasodilator therapy; 0.5-3 μg/kg/min nitroglyserin and/or 0.5-3 μg/kg/min nitroprusside, 5-15 μg/kg/min dobutamin and/or dopamin to keep systolic blood pressure above 80 mmHg. RESULTS: Thirteen patients ...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
Abstract Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathophysiologically critical renin angiotensin system (RAS). We, therefore, determined regulation patterns of key components of the RAS and the β-arrestin signaling pathways in left ventricular (LV) tissue specimens from 8 patients with end-stage ischemic cardio...
Source: Molecular and Cellular Biochemistry - Category: Biochemistry Authors: Tags: Mol Cell Biochem Source Type: research
More News: Cardiology | Cardiomyopathy | Children | Dilated Cardiomyopathy | Emergency Medicine | Girls | Heart | Heart Transplant | Hospitals | National Institute for Health and Clinical Excelle | Pediatrics | Sports Medicine | Transplant Surgery | Transplants