Correlation between renal function and peripapillary choroidal thickness in treatment na ïve diabetic eyes using swept-source optical coherence tomography.

This study included 1,408 diabetic patients, with a mean age of 64.4±7.8 years. The average pCT decreased with renal function deterioration, with 126.0 μm ± 58.0 μm for non-CKD, 112.0 μm ± 51.2 μm for mild CKD and 71.0μm ± 22.9 μm for MS-CKD, respectively (P
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research

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Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Khunti K, Davies MJ, Seidu S Abstract Introduction: Early initiated and long-term sustained intensive glucose control is associated with a significantly decreased risk of cardiovascular events and all-cause mortality, over and above the well-established decline in the risk of microvascular disease. Based on the recent cardiovascular outcome trial (CVOT) data, this review focuses on the various benefits of the newer medications with their positioning in the treatment algorithm and explores the place of the older medications in the management of type 2 diabetes mellitus (T2DM).Areas covered: We searched the ...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Authors: Ramachandran M, Loi B, Mat Ariff N, Ng OC, Zahari Sham SY, Thambiah SC, Samsudin IN Abstract INTRODUCTION: Metformin is the first-line pharmacological therapy for type 2 diabetes mellitus (T2DM). Guidelines recommend metformin to be given at reduced dosages for those with an estimated glomerular filtration rate (eGFR)
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
Response to letter to the editor by Dr. Tomoyuki Kawada: "Carotid intima-media thickness and cardiovascular risk in patients with diabetes mellitus type 2 and chronic kidney disease". Ren Fail. 2020 Nov;42(1):330-332 Authors: Georgiadis GS, Argyrio C, Roumeliotis A PMID: 32336210 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Conditions:   Chronic Kidney Disease Due to Hypertension;   Chronic Kidney Disease Due to Type 2 Diabetes Mellitus Interventions:   Biological: Faecal microbiota transplant;   Biological: Placebo Sponsor:   Hospital Universitario Dr. Jose E. Gonzalez Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article summarizes a presentation from a recent symposium entitled “SUs in the treatment of T2DM: a fresh look and new insights” held on 18 September 2019 during the 55th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Barcelona, Spain, and discusses whether sulfonylureas (SUs) are a good ‘team player.’ It examines the likely impact of using SUs early in the course of type 2 diabetes mellitus (T2DM), either alone or in combination with other agents, on glycemic outcomes and net side effects. The management of patients with T2DM and cardiovascular disease or chroni...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
AbstractKynurenine pathway of tryptophan metabolism is involved in the pathophysiology of chronic kidney disease (CKD) and diabetes mellitus, mainly through the inflammation-induced activity of indoleamine 2,3-dioxygenase (IDO), and few studies have investigated its potential link with proteinuria. Renin –angiotensin system inhibitors (RASis) are recommended in these patients to decrease proteinuria, slow CKD progression and reduce cardiovascular risk, but whether these drugs influence kynurenine levels in humans is unknown. We evaluated serum tryptophan and kynurenine in patients suffering from C KD with or without ...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions: In the whole study group, the risk of DR was associated with the duration of diabetes, HbA1c, triglyceride concentrations and smoking. In DM1 patients, the risk of DR was associated with diabetic kidney disease in the G1A1/A2 stage of chronic kidney disease, and in DM2 patients with the G2 stage of chronic kidney disease. An important risk factor for DR in DM2 patients was associated with late introduction of insulin therapy. PMID: 32295214 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Diabetes mellitus (DM) and chronic kidney disease (CKD) significantly increase the risk of cardiovascular morbidity and mortality. Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are a new class of hypoglycemic agents that have shown significant promise in the reduction of cardiovascular events. Current guideline recommendations do not support the use of these agents in patients with CKD stage 3 or higher. We performed a comprehensive meta-analysis to evaluate their cardiovascular effects in patients with type 2 DM and CKD stage 3 or higher. A comprehensive search was performed in PubMed, Cochrane central, and Embase. S...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Dominique E. Martin1,2, Amanda K. Jones1,3, Sambhu M. Pillai1,4, Maria L. Hoffman1,5, Katelyn K. McFadden1,6, Steven A. Zinn1, Kristen E. Govoni1 and Sarah A. Reed1* 1Department of Animal Science, University of Connecticut, Storrs, CT, United States 2Department of Psychology, Providence College, Providence, RI, United States 3Department of Pediatrics, School of Medicine, University of Colorado, Aurora, Aurora, CO, United States 4School of Medicine, Georgetown University, Washington, DC, United States 5Department of Fisheries, Animal and Veterinary Sciences, The University of Rhode Island, Kingston, RI, United St...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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