Determining Mycobacterium tuberculosis Drug Resistance and Risk Factors for Multidrug-Resistant Tuberculosis in Sputum Smear-Positive Tuberculosis Outpatients in Anhui Province, China, 2015 & ndash;2016
Conclusions: Over a 10-year study period, 24% of the TB patients were diabetic, nearly half were detected at the time of TB diagnosis. There may be a good case for screening all TB patients for DM.
Authors: Ndishimye P, Zakham F, Musanabaganwa C, Migambi P, Mihai C, Soritau O, El Mzibri M, Pop CM, Mutesa L Abstract The aim of the present study was to examine characteristics of tuberculosis (TB) patients with different clinical forms and to study the frequency of Regulatory T cells (Treg cells) and Activated T cells in patients with new active and relapse TB. Forty-five pulmonary TB patients and a control group of 15 healthy individuals were enrolled in this study. Of the 45 TB patients, 15 were new cases with drug-susceptible active TB and 30 were relapsed cases (15 drug-susceptible and 15 multidrug resistant...
CONCLUSION: This report describes high MTB and MDR-TB prevalence rates among symptomatic military patients with military personnel having higher odds of MTB infection compared to the civilian patients in the study. Since DSSM (ZN) sensitivity greatly varied depending on MTB load, the Xpert MTB/RIF should be used as a first-line diagnostic tool to identify MTB and detect rifampin resistance among presumptive TB cases instead of DSSM (ZN) microscopy. PMID: 31915831 [PubMed - as supplied by publisher]
CONCLUSIONS: Vitamin D supplementation had no beneficial effect on anti-TB treatment, but it reduced the time to sputum culture conversion in participants with tt genotype of the TaqI vitamin D receptor gene polymorphism and improved the MDR TB sputum culture conversion rate. PMID: 31833904 [PubMed - as supplied by publisher]
Background: Diabetes mellitus (DM) has an influence on many aspects of tuberculosis (TB).Objectives: to correlate the influence of diabetes mellitus on sputum conversion rate and antituberculous drug resistance.Methods: The study comprised 194 pulmonary tuberculosis (PTB) patients divided in two groups, i.e. the group of TB associated with DM and the group of patients affected only by TB. Sputum smear and liquid culture (MGIT 960) examination were performed at TB diagnosis and subsequently at completion of the initial phase as well as during the continuation phase of TB treatment. Drug sensitivity test (DST) was also perfo...
Conclusions: About half of the MDR-TB cases in our centre achieved successful treatment outcome. Poor treatment outcome was seen in male and smoker.
Tuberculosis (TB) is a leading cause of death and morbidity worldwide. Of the 10 million incidence cases of TB estimated in 2017, 10% were in children.The diagnosis of TB in the paediatric population remains challenging due to the paucibacillary nature of the disease. Culture confirmation is low for both pulmonary and extrapulmonary disease; 30.3% and 19.4% respectively resulting in empiric treatment for presumed TB. Mediastinal TB is a common presentation of TB in children but difficult to access for sampling.A retrospective case review of all children (
Conclusions: In Hanoi city, drug resistance-conferring mutations are prevailing differently depending on MTB lineages and treatment history. Confirmation of sterilizing cure is important for better TB control.
This study is to evaluate the performance of GeneXpert MTB/RIF (GXP) assay versus Real-time PCR MTBC/NTM (Lytestar) and other conventional methods in the diagnosis of Mycobacterium tuberculosis (TB). We conducted a retrospective cross-sectional analysis of patients who were investigated for TB via bronchoalveolar lavage between March to December 2018 in a single tertiary pulmonary centre in Malaysia. Results of GXP were analyzed base on patient’s demographic characteristics and other diagnostic methods. 33 of total 72 patients were diagnosed with pulmonary tuberculosis either through rapid DNA testing via GXP or real...
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.