Sinapic Acid Ameliorates Oxidative Stress, Inflammation, and Apoptosis in Acute Doxorubicin-Induced Cardiotoxicity via the NF- κB-Mediated Pathway.
Sinapic Acid Ameliorates Oxidative Stress, Inflammation, and Apoptosis in Acute Doxorubicin-Induced Cardiotoxicity via the NF-κB-Mediated Pathway. Biomed Res Int. 2020;2020:3921796 Authors: Bin Jardan YA, Ansari MA, Raish M, Alkharfy KM, Ahad A, Al-Jenoobi FI, Haq N, Khan MR, Ahmad A Abstract In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20 mg/kg; and group IV, administered DOX+captopril (CAP 30 mg/kg). SA and CAP were administered orally for seven days, and DOX (15 mg/kg) was injected intraperitoneally an hour before SA treatment on the fifth day. Forty-eight hours after DOX administration, animals were anesthetized and sacrificed for molecular and histology experiments. SA significantly mitigated the myocardial effects of DOX, and following daily administration, it reduced serum levels of lactate dehydrogenase (LDH) and creatine kinase isoenzyme-MB to near normal values. Levels of oxidative stress markers, glutathione-peroxidase, superoxide dismutase, and catalase, in the cardiac tissue were significantly increased, whereas malondialdehyde levels decreased after SA treatment in DOX-administered rats. Furthermore, DOX caused an inflammatory reaction by e...
He's talking so obviously moving air initially but definitely has the hypoxic hue wayy before they let off of him. Seriously, what were they thinking? Autopsy apparently says no sign of strangulation. But I'm thinking gradual desaturation -> LOC -> cardiac arrest. Thoughts? Found the full unedited video here:
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I am starting my third year of medical school at one of the ‘mid-tier’ University of Californias (not UCSF or UCLA) and just received my Step 1 score of 243. I have 3 pubs in anesthesia and surgery and 5 poster presentations. I grew up and have all my personal connections back in Southern California and it’s a major priority to go back home for residency second only to matching to my specialty of choice which is surgery. what are my chances as it stands right now stats wise to eventually... What are my chances for a general surgery program in CA?
Objective The aim of this study was to evaluate the ability of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) surgical risk calculator to predict surgical morbidity in patients undergoing pelvic reconstructive surgery. Methods This was a retrospective study of patients who underwent pelvic reconstructive surgery from 2014 to 2017. Preoperative risk factors were abstracted from medical records and entered into the ACS NSQIP surgical risk calculator. The Current Procedural Terminology code that produced the largest risk was used and compared with actual patient outcomes. Demog...
Authors: Lee J, Kim Y, Mun J, Lee J, Ko S Abstract Background: The present study was designed to evaluate the effects of hypercarbia on arterial oxygenation during one-lung ventilation (OLV). Methods: Fifty adult patients undergoing elective video-assisted thoracoscopic lobectomy or pneumonectomy were enrolled. Group 1 patients (n = 25) were first maintained in normocarbia (PaCO2: 38 - 42 mmHg) for 30 min and then in hypercarbia (45 - 50 mmHg). In group 2 patients (n = 25), PaCO2 was maintained in the reverse order. Arterial oxygen partial pressure (PaO2), respiratory variables, hemodynamic variables, and hemog...
Authors: Singh A PMID: 32460464 [PubMed - as supplied by publisher]
Publication date: Available online 29 May 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Geoffrey Ho, Everett Chu, Kyung Min Lee, Murwarit Rahimi, Anna K. Hindle, Raymond Pla, Ivy Benjenk, Eric Heinz
Publication date: Available online 29 May 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Tasneem F. Hasan, Roger E. Kelley, Elyse M. Cornett, Richard D. Urman, Alan D. Kaye
Publication date: Available online 29 May 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Shilpadevi S. Patil, Lu Sun, Charles J. Fox, Kathryn E. Anthony, Fallon A. Anzalone, Paul M. Fisher, Brook Girma, Genkai J. Huang, Emily L. Barsley, Elyse M. Cornett, Richard D. Urman, Alan D. Kaye
Publication date: Available online 22 April 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Alexander Gomelsky, Kenneth Abreo, Nazih Khater, Adrian Abreo, Bakhtiar Amin, Madelyn K. Craig, Amit Prabhakar, Elyse M. Cornett, Richard D. Urman, Alan D. Kaye