Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study

Conclusions/interpretationThe present study strengthened the evidence that MDD is a potential risk factor for type 2 diabetes and CAD. Whether MDD is causally related to heart failure needs further study.Data availabilityAll data included in this study were uploaded as supplements and are also publicly available through published GWASs and open GWAS datasets (UK Biobank, 23andMe and Psychiatric Genomics:https://datashare.is.ed.ac.uk/handle/10283/3203; DIAGRAM:http://diagram-consortium.org/downloads.html; CARDIoGRAMplusCD4:www.cardiogramplusc4d.org/; HERMES:http://www.kp4cd.org/datasets/mi).Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research