NADf Chip, a Two-Color Microarray for Simultaneous Screening of Multigene Mutations Associated with Hearing Impairment in North African Mediterranean Countries
Hearing impairment (HI) is the most frequent sensory defect. Genetic causes are involved in two thirds of prelingual cases. Moreover, the autosomal recessive HI frequency is increased in countries where there is a high rate of consanguinity, such as in North African Mediterranean countries. This population shares several features, including history and social behavior, that promote the spread of founder mutations. HI is characterized by tremendous heterogeneity in both the genetic and clinical aspects.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Imen Chakchouk, Mariem Ben Said, Fida Jbeli, Riadh Benmarzoug, Salma Loukil, Ibtihel Smeti, Amine Chakroun, Abdullah Ahmed Yousef Gibriel, Abdelmonem Ghorbel, Hassen Hadjkacem, Saber Masmoudi Tags: Regular Article Source Type: research