Exercise-Induced Cognitive Improvement Is Associated with Sodium Channel-Mediated Excitability in APP/PS1 Mice.

This study suggests that exercise improves cognition and neural activity by altering the numbers and distribution of hippocampal Nav in APP/PS1 mice. Long-term treadmill exercise, for about 24 weeks, starting in the preclinical stage, is a promising therapeutic strategy for preventing AD and halting its progress. PMID: 32256560 [PubMed - as supplied by publisher]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research

Related Links:

FDA approved Tauvid for IV injection, the first drug used to help image a distinctive characteristic of Alzheimer ’s disease in the brain called tau pathology. Tauvid is a radioactive diagnostic agent for adult patients with cognitive impairment who are being evaluated for Alzheimer’s disease.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Conclusions: AD and CVD are frequently associated. Further studies are needed in order to understand the effect of CVD and its risk factors on AD in order to better comprehend the effects of subclinical and clinical CVD on the brain. Finally, we need to clarify the impact of the underlying hypothesized mechanisms of this association and to investigate gender issues. PMID: 32454996 [PubMed]
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Older people who have large body weight fluctuations may have an increased risk for developing dementia and Alzheimer’s, according to a study published inFrontiers in Endocrinology. Endocrinology Advisor
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
CONCLUSION: Limbic-predominant age-related TDP-43 encephalopathy is uniquely associated with distinct longitudinal profiles of financial and health literacy in old age. PMID: 32452861 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Yakeel T Quiroz, Henrik Zetterberg, Eric M Reiman, Yinghua Chen, Yi Su, Joshua T Fox-Fuller, Gloria Garcia, Andres Villegas, Diego Sepulveda-Falla, Marina Villada, Joseph F Arboleda-Velasquez, Edmarie Guzmán-Vélez, Clara Vila-Castelar, Brian A Gordon, Stephanie A Schultz, Hillary D Protas, Valentina Ghisays, Margarita Giraldo, Victoria Tirado, Ana Baena
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: June 2020Source: The Lancet Neurology, Volume 19, Issue 6Author(s): Colin L Masters
Source: The Lancet Neurology - Category: Neurology Source Type: research
Contributors : Kirk B Burkhart ; Steven R Sando ; Anna Corrionero ; H R HorvitzSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMaternally inherited RNA and protein control much of embryonic development. The impact of such maternal information beyond embryonic development is largely unclear. Here we report that maternal contribution of histone H3.3 assembly complexes can prevent the expression of late-onset anatomical, physiologic, and behavioral abnormalities of C. elegans. We show that mutants lacking hira-1, an evolutionarily conserved H3.3-deposition factor, have severe p...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Caenorhabditis elegans Source Type: research
Publication date: Available online 26 May 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Mahdi Ramezani, Alireza Komaki, Nasrin Hashemi-Firouzi, Keywan Mortezaee, Nafiseh Faraji, Zoleikha Golipoor
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Photo credit Aris Fackenakis The truth, as they see it, is still the truth in their eyes. Delusions, hallucinations, agitation, aggression, and depression are all part of the gradual progression of psychosis of patients with Alzheimer ’s disease (AD). An average of 41% of these patients will experience these psychotic symptoms. One of the most common delusions these patients have are theft-related. An experienced caregiver offers her advice on how to deal with accusations of theft, which are common in dementia patients. Continue reading on Agingcare for more about how Alzheimer's - yes even younger-onset Alzheimer's ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We propose that factors that influence the nervous system may also affect the volume, viscosity, porosity of mucus composition and subsequently, gastrointestinal (GI) microbial populations. The gut has its own intrinsic neuronal network, the enteric nervous system, which extends the length of the GI tract and innervates the mucosal epithelium. The ENS regulates gut function including mucus secretion and renewal. Both dysbiosis and gut dysfunction a...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
More News: Alzheimer's | Brain | Neurology | Sodium | Sports Medicine | Study