Contrast medium-induced severe thrombocytopenia in patient on maintenance hemodialysis: a case report and literature review

AbstractA 43-year-old male patient on maintenance hemodialysis had an enhanced computed tomography scan examination with iohexol for the first time 10  min before regular hemodialysis therapy. At the start of hemodialysis, no symptoms were observed, and the platelet count was 148,000/μl. Approximately 1 h after starting hemodialysis, dyspnea and chest discomfort appeared. Since oxygen saturation of the peripheral artery decreased to 87%, oxygen administration was immediately started while continuing hemodialysis therapy. Furthermore, gingival hemorrhage was observed, and the platelet count decreased to 5000/μl. We were carefully monitoring his conditions while continuing hemodialysis and oxygen administration, but no further deterioratio n was observed. Thereafter, these symptoms and severe thrombocytopenia gradually improved without additional treatment. At the end of hemodialysis, these symptoms completely disappeared. As well, the platelet count recovered to 35,000/μl at the end of hemodialysis and increased to 92,000/μl the ne xt morning. From the clinical course, we diagnosed with contrast medium-induced thrombocytopenia. Acute thrombocytopenia is a rare complication induced by the contrast medium. Until now, 16 cases on contrast medium-induced thrombocytopenia have been reported. Our case spontaneously recovered from se vere thrombocytopenia relatively earlier than previous reports. Our patient started hemodialysis therapy 10 min after an enha...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research

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Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Publication date: Available online 25 May 2020Source: The Lancet HaematologyAuthor(s): Wanxin Chen, Bohan Yang, Ziping Li, Ping Wang, Yan Chen, Hao Zhou
Source: The Lancet Haematology - Category: Hematology Source Type: research
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Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
AbstractTo review the efficacy and safety of glucocorticoids combined with different regimens for treating severe immune thrombocytopenia (ITP). Eighty-five severe ITP patients from 2 tertiary hospitals treated with glucocorticoids were enrolled from January 2018 to May 2019 and divided into 4 treatment groups: group A (treated with glucocorticoids), group B (glucocorticoids plus intravenous immunoglobulin (IVIg)), group C (glucocorticoids plus recombinant human thrombopoietin (rhTPO)), and group D (glucocorticoids plus IVIg and rhTPO). Statistical analysis was performed with SPSS 19.0 software. Early responses and respons...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
ABSTRACTStability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg1 to describe drug ‐induced haematotoxicity is widely used to support decisions across drug development, and parameter values are often identified from observed blood counts. We use stability analysis to study the parametric dependence of stable and unstable solutions of several Friberg‐type models, and highlight the risks associated with system instability in the context of non‐linear mixed effects modelling. We emphasize the consequences of unstable solutions on prediction perfor...
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ARTICLE Source Type: research
Authors: Humbert S, Razanamahery J, Payet-Revest C, Bouiller K, Chirouze C PMID: 32445664 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Pituitary apoplexy is a rare but life-threatening condition caused by sudden hemorrhage or infarction of the pituitary gland (1). The prevalence of this complication is approximately 8% in patients with preexisting nonfunctioning pituitary macroadenoma(2). It can result in rapid bilateral vision loss, altered mental status, panhypopituitarism, and increased intracranial pressure (3). Impaired coagulation status is one of the precipitating causes of pituitary apoplexy. Patients who undergo hematopoietic cell transplantation (HCT) develop significant thrombocytopenia, which puts them at higher risk for apoplexy (4).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Publication date: Available online 22 May 2020Source: Life SciencesAuthor(s): Seyedeh Sahar Mortazavi Farsani, Majid Sadeghizadeh, Mohammad Ali Gholampour, Zohreh Safari, Farhood Najafi
Source: Life Sciences - Category: Biology Source Type: research
Authors: Rath W, Tsikouras P, Stelzl P Abstract HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. A specific risk profile does not exist for either of the entities. Genetic defects in mitochondrial fatty acid oxidation and multiple pregnancy are considered to be common predisposing factors. The dia...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
This study examined whether the combination of hematological indices and FI can be used as an early diagnostic tool for NEC or sepsis. Study Design This retrospective cohort study included infants born at
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
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