The Role of B Cells in the Immunopathogenesis of Multiple Sclerosis.

The Role of B Cells in the Immunopathogenesis of Multiple Sclerosis.
Immunology. 2020 Apr 06;:
Authors: Gharibi T, Babaloo Z, Hosseini A, Marofi F, Ebrahimi-Kalan A, Jahandideh S, Baradaran B
Abstract
Over the last years, there has been an ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B cell targeting therapies in MS highlighted the role of B cells particularly the antibody-independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system (CNS). Here, we discuss the role of different antibody-dependent and antibody-independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B cell targeting treatments.
PMID: 32249925 [PubMed - as supplied by publisher]

Source: Immunology - April 5, 2020 Category: Allergy & Immunology Authors: Gharibi T, Babaloo Z, Hosseini A, Marofi F, Ebrahimi-Kalan A, Jahandideh S, Baradaran B Tags: Immunology Source Type: research