Putting remdesivir to the test for COVID-19

(American Chemical Society) As the coronavirus pandemic claims lives and overwhelms health care systems throughout the world, scientists are closely watching several late-stage trials of the antiviral drug remdesivir. Developed to treat Ebola, remdesivir is now being tested against COVID-19. However, many infectious disease experts caution that the trials are unlikely to yield clear-cut results, according to an article inChemical&Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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By Carol Bales , Advocacy and policy communications manager, IntraHealth International ; Casey Bishopp, Communications officer, IntraHealth InternationalMay 22, 2020Here in North Carolina, we all know someone who works in health care. Maybe there’s a nurse in your family, a physician, a data clerk, a pharmacist.These“frontline health workers” are in the spotlight right now as they face unprecedented dangers during every shift they work.Frontline health workers are literally putting themselves on the line—at great personal risk—to respond to COVID-19, stop its spread, and save their patient...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Infectious Diseases COVID-19 Advocacy Health Workers Source Type: news
Abstract Acute lung injury (ALI) represents the most severe form of the viral infection sustained by coronavirus disease 2019 (COVID-19). Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. In fact, ALI seems to be related to the inflammatory burst and release of proinflammatory mediators that i...
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research
On May 1, the U.S Food and Drug Administration issued an emergency-use authorization of remdesivir, an experimental anti-viral drug. With this clearance, doctors in the U.S. are now allowed to use the drug to treat patients with severe cases of COVID-19. Remdesivir isn’t new. It was initially developed to treat Ebola and was also tested in the lab against SARS and MERS—two other coronaviruses that infect humans much like the virus that causes COVID-19. It never made it to the approval stage for those uses, but over the last four months, scientists desperate for options to help mitigate the coronavirus pandemic ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
This study showed that a five-day regimen is as effective as 10 days–that’s important, doctors say, since it could mean shorter stays in the hospital, which could alleviate some of the burden on the health care system. “Of course we will have to wait for the final review of all the data, but it would be very nice to have an anti-viral that’s efficacious in this terrible illness,” says Dr. Aruna Subramanian, a clinical professor of medicine at Stanford and an investigator on the study. “At least we know that we can help patients with this, and that’s really the bottom line.” T...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Magazine Source Type: news
In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is neither a vaccine nor proven treatment for COVID-19, there is currently an urgent need for effective pharmacotherapy. To address the need for an effective treatment of SARS-CoV-2 during the worldwide pandemic, this systematic review of intravenous (IV) remdesivir was performed. Remdesivir, an anti-viral prodrug originally developed to treat Ebola virus disease, has shown b...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
Patients lie motionless in a hospital ICU ward, as doctors hurry around their beds. The patients’ faces are concealed by ventilators; the doctors’ by masks. The death rate is rising so quickly that doctors can no longer keep count. “The beds don’t even have time to cool before they are taken up by other patients,” says ICU nurse Cristina Pilati. Yet over the sound of stretchers rolling and monitors beeping, Pilati starts singing the lyrics of ‘Angel’ as she cares for a teenage boy in the ICU. ‘Spend all your time waiting, for that second chance,’ she sings. ‘For a...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Londontime Source Type: news
By CASEY QUINLAN, HELEN HASKELL, BILL ADAMS, JOHN JAMES, ROBERT R. SCULLY, and POPPY ARFORD Last year, the Patient Council of the Right Care Alliance conducted a survey in which over 1,000 Americans answered questions about what worried them most about their healthcare. We asked questions about access to care, concerns about misdiagnosis, and risks of treatment, which we reported on in our last THCB piece about the What Worries You Most survey. We also asked people to rank their concerns about the costs of their care, in five questions that covered cost of care, cost of prescription drugs, cost and availability of in...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Health Policy Bill Adams Casey Quinlan cost of care Costs Economics Health Care Costs Helen Haskell John James Patient Council of the Right Care Alliance Poppy Arford Robert R. Scully Source Type: blogs
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue remdesivir (RDV). RDV shows broad-spectrum antiviral activity against RNA viruses, and previous studies with RdRps from Ebola virus and Middle East respiratory syndrome coronavirus (MERS-CoV) have revealed that delayed chain termination is RDV's plausible mechanism of action. Here, we exp...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
Abstract During the initial stages of the COVID-19 epidemic, one of the responsibilities assigned to local health departments (LHDs) was to monitor travelers returning from mainland China. The Centers for Disease Control and Prevention (CDC) defined this intervention as "self-monitoring with public health supervision" (a full description is provided at https://www.cdc.gov/coronavirus/2019-ncov/php/risk-assessment.html). This type of self-monitoring under public health supervision for returning travelers was implemented recently with other communicable diseases, such as Ebola.1. (Am J Public Health. Publi...
Source: Am J Public Health - Category: International Medicine & Public Health Authors: Tags: Am J Public Health Source Type: research
SG Patricia Scotland and President Kagame of Rwanda last year during the annual commemoration of the genocide against the Tutsis. Credit: The Commonwealth SecretariatBy William EllisTORONTO, May 13 2020 (IPS) The Coronovirus pandemic has been an unforgiving test of advanced economies. Health systems in the United States, France, Italy, Spain, and the UK have been put under immense pressure, with shortages of doctors, ventilators, personal protective equipment and the capacity to test for the virus. Their economies have been battered and the consequences are spoken of in terms of the Great Depression. Hope may have emerged...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Economy & Trade Featured Financial Crisis Global Globalisation Headlines Health Humanitarian Emergencies TerraViva United Nations Source Type: news
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