Effects of Andersson lesion treatment in ankylosing spondylitis: A medical record review study focused on medium ‐ to long‐term outcomes
AbstractThe present study aimed to evaluate the clinical efficacy of Andersson lesion (AL) treatments and prognostic factors using medium ‐ to long‐term follow‐up data and discuss the clinical characteristics and treatment of AL. Forty‐eight consecutive AL cases at our center from June 2011 to March 2018 were retrospectively analyzed, including 13 cases treated conservatively and 35 treated surgically. Epidemiological characte ristics, treatment modalities, clinical features and outcomes, and prognostic factors of the Japanese Orthopaedic Association (JOA) recovery rate were reviewed. Neurological functional recovery was evaluated by American Spinal Injury Association (ASIA) classification. Clinical efficacy was evaluated by JOA score, visual analog scale (VAS) score, and Cobb's angle. The mean overall follow‐up duration was 44.5±18.5 months (range, 27–85 months). There were 36 male and 12 female patients, with a mean age of 49.4±13.1 years (range, 26–72 years). The most common lesion location was the thorac olumbar region, i.e., T10‐L2 (n=33; 68.8%), followed by the thoracic (n=10) and lumbar (n=5) regions. Patients treated surgically showed significantly better JOA scores, VAS scores and Cobb's angles at the final follow‐up than did patients treated conservatively (P
Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood.
ConclusionsGolimumab had a definite effect in the treatment of AS. The higher dose would obtain better efficacy but lead to the incidence of SAE.
ConclusionParadoxical skin reactions are an emerging clinical entity that require further research in order to establish risk factors and best personalized treatment.
What Are the Early Symptoms of Ankylosing Spondylitis?
Co-stimulatory T-cell inhibitors are used in the treatment of rheumatoid arthritis and to prevent rejection of renal transplants. Inhibitors of the intereukin (IL-17) cytokine are indicated for psoriasis, psoriatic arthritis and ankylosing spondylitis and anti- IL-23 drugs for psoriasis. Serious infections occur in 4.2% to 25.0% of co-stimulatory inhibitors and 1.0% to 2.0% with IL-17 or IL-23 inhibitors. Underlying disease, steroid dose greater than 7.5 to 10.0 mg, and comorbidities influence risk in individual patients. Opportunistic infections or reactivation of tuberculosis are rare.
Condition: AS Intervention: Device: Bone Mineral Density and Trabecular Bone score Sponsor: Mansoura University Completed
CONCLUSION: Patients with AS have higher odds of having HL over patients without AS. This population also presents with significantly impaired hearing thresholds across all conventional and extended pure tone frequencies. This may manifest as slight to moderate hearing loss. Results of this systematic review might justify increased attention audiologic manifestations of patients with AS. PMID: 32414955 [PubMed - as supplied by publisher]
AbstractTo review the effect of tumor necrosis factor ‐alpha inhibitor (TNFi) therapies on radiographic progression in ankylosing spondylitis (AS) patients as evaluated by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Pubmed, MEDLINE, EMBASE, and the Cochrane Library databases were searched from inception to August 2019. All compara tive and non‐comparative studies that evaluated the clinical effectiveness of TNFi on radiographic progression as assessed by mSASSS change at a minimum follow‐up of 1 year were included. The Newcastle–Ottawa Scale and Cochrane Collaboration Risk of Bias Tool ...
Diagnosing and treating low back pain (LBP) is a worldwide major primary care challenge in which a differential diagnosis between non-specific LBP and conditions with a known pathology is essential for choosin...
CONCLUSIONS: PSO can provide acceptable radiographic outcomes for the correction of thoracolumbar kyphosis in patients with AS. However, a high incidence of surgery-related complications related to mechanical failure and surgical technique can develop. Thorough radiographic investigation before and during surgery is needed to determine whether complete ossification occurs along the anterior and posterior longitudinal ligaments of the spine. PMID: 32413867 [PubMed - as supplied by publisher]