Performance of an Automated Workflow for Magnetic Resonance Imaging of the Prostate: Comparison With a Manual Workflow

Objectives The aim of this study was to evaluate the performance of an automated workflow for multiparametric magnetic resonance imaging (mpMRI) of the prostate compared with a manual mpMRI workflow. Materials and Methods This retrospective study was approved by the local ethics committee. Two MR technicians scanned 2 healthy volunteers with a prototypical highly automated workflow (Siemens Healthineers GmbH, Erlangen, Germany) and with a manually adjusted scan protocol each. Thirty patients (mean age ± standard deviation, 68 ± 11 years; range, 41–93 years) with suspected prostate cancer underwent mpMRI on a 3 T MRI scanner. Fifteen patients were examined with the automated workflow and 15 patients with a conventional manual workflow. Two readers assessed image quality (contrast, zone distinction, organ margins, seminal vesicles, lymph nodes), organ coverage, orientation (T2w sequences), and artifacts (motion, susceptibility, noise) on a 5-point scale (1, poor; 5, excellent). Examination time and MR technicians' acceptance were compared between both groups. Interreader agreement was evaluated with Cohen's kappa (κ). Results The automated workflow proved consistent for sequence orientation and image quality in the intraindividual comparisons. There were no significant differences in examination time (automated vs manual; median 26 vs 28 minutes; interquartile range [IQR], 25–28 minutes each; P = 0.57), study volume coverage, artifacts, o...
Source: Investigative Radiology - Category: Radiology Tags: Original Articles Source Type: research

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Cancers, Vol. 12, Pages 1248: Multi-Modal PET and MR Imaging in the Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) Model for Initial in Vivo Testing of Target-Specific Radioligands Cancers doi: 10.3390/cancers12051248 Authors: Gordon Winter Andrea B. F. Koch Jessica Löffler Mika Lindén Christoph Solbach Alireza Abaei Hao Li Gerhard Glatting Ambros J. Beer Volker Rasche The validation of novel target-specific radioligands requires animal experiments mostly using mice with xenografts. A pre-selection based on a simpler in vivo model would allow to reduce the number of animal exp...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractBackground and objectiveThe optimal management of prostate cancer (PC) recurrences after definitive or postoperative radiotherapy (RT) is still controversial. The aim of the present retrospective study was to report the preliminary clinical results and toxicity of a  mono-institutional series of patients re-irradiated with linac-based SBRT in recurrent prostate cancer.MethodsInclusion criteria were previous definitive or adjuvant/salvage RT, evidence of biochemical recurrence and radiological detection of local relapse (Magnetic Resonance Imaging or PSMA/choline-Positron Emission Tomography), and IPSS
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
Conclusion: We have shown that there are quantitative imaging features that are reproducible across sequential prostate mpMRI acquisition at a preset level of filters. We also found that a habitat approach improves feature repeatability in ADC. A validated set of reproducible image features in mpMRI will allow us to develop clinically useful disease risk stratification, enabling the possibility of using imaging as a surrogate to invasive biopsies.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
We present a case of a 79 year old patient with a medical history of unilateral nerve-sparing radical prostatectomy due to a pT3aN0 (Gleason score 7) prostate carcinoma. Because of slightly elevated prostate specific antigen (PSA) level (0.35ng/dL), a fluorine-18-prostate specific membrane antigen (18F-PSMA)-1007 positron emission tomography/computed tomography (PET/CT) scan was performed, showing no signs of malignant recurrence. However, a moderately PSMA-avid nodular lesion was observed in the left occipital region with homogeneous contrast enhancement, suggestive for a meningioma, which was confirmed on magnetic resona...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
CONCLUSION: Carbon-11-choline PET was found have a greater correlation with Gleason score than DWI and is considered to be more useful to predict a higher score in patients with prostate cancer. Fluorine-18-FDG PET was limited because of low sensitivity. PMID: 32222730 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
The diagnostic performance of 18F-sodium fluoride positron emission tomography/computed tomography (PET/CT) (NaF), 18F-fluorocholine PET/CT (FCH) and diffusion-weighted whole-body magnetic resonance imaging (DW-M...
Source: BMC Medical Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
Publication date: Available online 18 February 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Devaki Shilpa Sudha Surasi, Brian Chapin, Chad Tang, Gregory Ravizzini, Tharakeswara Kumar BathalaAbstractProstate cancer (PCa) is the most common non-cutaneous malignancy in men and the second leading cause of cancer related death in the United States. Men with clinical suspicion of PCa undergo tissue sampling and based on features including the Gleason score, Prostate Specific antigen (PSA) levels and clinical tumor (T) stage, patients are risk stratified into 6 major groups based on National Comprehensive Cancer Netwo...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
In this study, the feasibility of the quantification of prostate cancer aggressiveness using parametric methods assessing [11C]-acetate kinetics was investigated in prostate cancer subjects. The underlying uptake mechanism correlated with [11C]-acetate influx and efflux measured in real-time in vitro in cell culture. Methods: Twenty-one patients with newly diagnosed low-to-moderate risk prostate cancer underwent magnetic resonance imaging (MRI) and dynamic [11C]-acetate PET/CT examinations of the pelvis. Parametric images of K1 (extraction × perfusion), k2 (oxidative metabolism) and VT (=K1/k2, anabolic metabolism de...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
AbstractImaging plays an increasing role in prostate cancer diagnosis and staging. Accurate staging of prostate cancer is required for optimal treatment planning. In detecting extraprostatic cancer and sites of early recurrence, traditional imaging methods (computed tomography, magnetic resonance imaging, radionuclide bone scan) have suboptimal performance. This leaves a gap between known disease recurrence as indicated by rising prostate-specific antigen and the ability to localize the recurrence on imaging. Novel positron emission tomography (PET) agents including radiolabeled choline, fluciclovine (18F-FACBC), and agent...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Conclusions: mpMRI can provide additional information for the detection of prostate cancer before saturation biopsies.Level of Evidence: III. PMID: 32026731 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
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