COVID-19 rapid guideline: severe asthma guidance (NG166)

The purpose of this guideline is to maximise the safety of adults and children with severe asthma during the COVID-19 pandemic, while protecting staff from infection.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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VERDICT: It is unclear if people with asthma are at increased risk of contracting COVID-19 or of worse outcomes from COVID-19 infection. The evidence available is limited with some sources suggesting an underrepresentation of PWA in hospitalised cases, and others showing an increased risk of worse outcomes in PWA which may be associated with disease severity. Consensus broadly holds that asthma medications should be continued as usual. Asthma care may be disrupted during the pandemic; self-management and remote interventions may be of benefit but have not been tested in this context.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
The Coronavirus Disease 2019 (COVID-19) pandemic has created unique challenges for emergency care providers and patients alike. While the rise in COVID-19 patients requiring inpatient care has led to overcrowding in some emergency departments (ED), discharging stable patients from the ED has also become more complicated in the COVID-19 era [1]. Prior to COVID-19, patients often used EDs for low acuity conditions (e.g., asthma, cellulitis, urinary tract infection) that are treatable with short courses of outpatient medications.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
When Eric Freeland, 34, started coughing at the end of March, he didn’t think much of it. But when his symptoms grew worse, Freeland’s mother began to worry. Freeland is a Native American living with his family in the Navajo Nation in the southwestern U.S., where access to healthcare is limited. He is also diabetic, putting him at greater risk to the coronavirus. When Freeland’s breathing became short and stuttered, his mother drove him to the nearest hospital where within minutes of arriving, he lost consciousness. He awoke three weeks later, hooked up to a ventilator, from a medically induced coma. &l...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 feature Londontime Source Type: news
AbstractCoronavirus disease 2019 (COVID-19) is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and abnormal, overactivated innate immunity and “cytokine storms” have been proposed as potential pathological mechanisms for rapid COVID-19 progression. Theoretically, asthmatic patients should have increased susceptibility and severity for SARS-CoV-2 infection due to a deficient antiviral immune response and the tendency for exacerbation el icited by common respiratory viruses. However, existing studies have not shown an expected prevalence of asthmatic in...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
ougheed MD PMID: 32473948 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
By ANISH MEHTA, MD My practice received its first question about coronavirus from a patient on January 28, 2020. Though there were over 200 deaths reported in China by that time, no one could have imagined how drastically this would come to disrupt our lives at home. Thankfully, I had a head start. As a doctor at an integrated telemedicine and primary care practice in New York City, nearly two out of every three of my medical encounters that month was already virtual. I spent much of January caring for patients who had contracted seasonal viruses, like influenza or norovirus (i.e. the stomach flu). My patients ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
Millions of people with underlying health conditions have not left the house for more than two monthsGlobal coronavirus updates - liveCoronavirus latest: at a glance“Shielding is lonely, hard work and stressful,” says Vicki Milner, 26, in Bristol. Her asthma means Milner’s lung capacity is that of someone in their 50s. She is one of millions of people with underlying health conditions in the UK who are shielding during the coronavirus pandemic, meaningthey are not leaving their home at all, even for exercise or food shopping.Milner, who works as a solicitor, is not on the limited government shielding list...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Communities Health Coronavirus outbreak Infectious diseases Science Society UK news Source Type: news
The potential detrimental effects of steroids on the immune system to fight viral infections had always been a concern for patients on long term steroids in chronic conditions. A recent warning from WHO on systemic corticosteroid use amid COVID-19 raised suspicion among public and healthcare professionals regarding the safety of steroid use during the SARS-CoV-2 pandemic. The corticosteroids (inhaled and oral) are commonly prescribed in the management of asthma and COPD patients and any unsolicited changes in medications use may lead to potentially severe exacerbations and risk patient lives.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Coronavirus disease 2019 (COVID-19) is caused by a novel zoonotic coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been identified as a pandemic by the World Health Organization. Several risk factors have been identified for severe COVID-19 –associated pneumonia including increased age and the presence of comorbidities, in particular diabetes, cardiovascular disease, and tobacco smoking.1 However, a number of reports have failed to identify excess risk in patients with respiratory airway diseases such as asthma.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
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