LncRNA GAS5 exacerbates myocardial ischemia-reperfusion injury through regulating serpina3 by targeting miR-137

We carefully read with interest the recent article by Zhao et al. [1] concerning “Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction”. This suggests that serine proteinase inhibitor A3 (Serpina3), also called alpha-1antichymotrypsin, may be a powerful prognostic biomarker for major adverse cardiovascular events in pati ents with acute myocardial infarction (MI). Although the exact mechanism is still unclear, this finding means that inhibition of Serpina3 may act as a potential therapeutic strategy for myocardial ischemia/reperfusion (I/R) injury heart.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Letter to the Editor Source Type: research