Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy.

Conclusions: We demonstrated histological evidence of persistent ectopic synapses, prolonged cellular apoptosis, and gliosis in the OIR retina that corresponded with long-term in vivo evidence of capillary attrition, inner retinal thinning, and dysfunction despite full peripheral revascularization. Further studies on the mechanisms underlying these persistent phenotypes could enhance our understanding of ROP pathogenesis and lead to new therapeutic targets to preserve visual function in premature infants. PMID: 32256029 [PubMed - as supplied by publisher]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research