Resolvin D1 Prevents the Impairment in the Retention Memory and Hippocampal Damage in Rats Fed a Corn Oil-Based High Fat Diet by Upregulation of Nrf2 and Downregulation and Inactivation of p66Shc.

In conclusion, CO-HFD impairs memory function and induces hippocampal damage by reducing levels of RvD1 and activation of JNK/p53/p66Shc/NADPH oxidase, effects that are prevented by co-administration of RvD1. PMID: 32253649 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32253649?dopt=Abstract

Source: Neurochemical Research - April 5, 2020 Category: Neuroscience Authors: Mostafa DG, Satti HH Tags: Neurochem Res Source Type: research