Transforming human ES or IPS cells into functional lung epithelial cells
For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center (CUMC) researchers, has significant potential for modeling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation. The study was published in the journal Nature Biotechnology.
CONCLUSIONS/IMPLICATIONSThis study provides a baseline assessment for examining trends in 30-day unplanned pediatric readmissions, an important quality metric as the provisions of the Children's Health Insurance Program Reauthorization Act and the Affordable Care Act are changed and implemented in the future. Over 50,000 pediatric hospital stays in 2014 occurred within 30 days of a previous hospitalization, with an average cost of $13,800. This report is timely, as the health care system works to become more patient-centered and public and private payers grapple with how to pay for quality care for children. The report pro...
ConclusionThis study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia.
This study aimed to evaluate how polymorphisms in DAD1 and OXA1L are associated with asthma and markers of atopy in individuals from the Salvador cohort of the SCAALA (Social Change Asthma and Allergy in Latin America) program. The DNA of 1220 individuals was genotyped using the Illumina 2.5 Human Omni Bead chip. Logistic regression analyses were performed with PLINK 1.9 software to verify the association between DAD1 and OXA1L polymorphisms and asthma and atopic markers, adjusted for sex, age, helminth infections and ancestry markers, using an additive model. The DAD1 and OXA1L genes were associated with some of the evalu...
(European Lung Foundation) The European Respiratory Society International Congress will take place at the Paris Expo Porte de Versailles from September 15 to 19, 2018.The Congress will be attended by the world's leading respiratory experts who will present cutting-edge research in a large and varied scientific program. Over 4,000 abstracts will cover a diverse range of disease areas and specialisms, including lung cancer, asthma and COPD, children's lung health, personalized medicine, e-cigarettes, AI and risk factors.
ConclusionsIn patients with nasal polyposis, asthma may alter the redox profile associated with the hydrogen peroxide and lipid damage pathways, whereas asthma and intolerance to acetylsalicylic acid increase nitrite and nitrate and total glutathione levels.
The objective of this study is to analyze the relationship between chronic rhino-sinusitis (CRS) and systemic symptoms in patients with IgG4-related disease (IgG4-RD).Patients and methodsThe patients with IgG4-RD, confirmed by restrict association with clinical and histopathological manifestations between March 2013 and July 2016, were enrolled and followed-up for 1 year at the Tongren Hospital, Capital Medical University. The patients were divided into two groups: the case group included IgG4-RD patients with CRS confirmed by clinical and imaging, while the control group included IgG4-RD patients without CRS confirm...
ConclusionThis study showed a significant association between polypoid change of anterior free border of middle turbinate and nasal polyp relapse. This new and simple criterion of severity of CRSwNP could have clinical implications.
To get a grasp of the socioeconomics of atopic dermatitis (AD), we need to understand its prevalence in the population, its burden, co-morbidities, and costs, both direct and indirect. Only then can we extrapolate whether it makes sense for society to cover new, more costly treatments in the management of this condition. AD affects a large percentage of the pediatric and adult population in the United States. 1 Generally, this chronic inflammatory condition of the skin has no mortality, which has to weigh into assessing the socioeconomics of this disorder.
Atopic Dermatitis (AD) prevalence and risk factors in the US-population are not fully elucidated. A study from the 2010 National Health Interview Survey (NHIS) found that 10.2% of US adults reported having “dermatitis, eczema, or any other red, inflamed skin rash”1 in the past 12 months, likely overestimating AD prevalence by including other rashes. Further, 3.2% reported having rash with asthma and/or hay fever1, likely underestimating AD prevalence by excluding intrinsic AD or those with remote history of atopic disease.
Previous studies suggest inclusion of baked egg and milk in the diet of egg or cow's milk (CM) allergic children may positively impact native tolerance. Differences in native food reactivity based on historical baked tolerance, however, is not fully understood. Objective: To assess differences in native egg and CM oral food challenge (OFC) outcomes based on presenting history of tolerance and exposure to these foods in the baked form.