Transforming human ES or IPS cells into functional lung epithelial cells

For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center (CUMC) researchers, has significant potential for modeling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation. The study was published in the journal Nature Biotechnology.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

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Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study also revealed adenosine as a novel danger-associated molecular pattern (DAMP), responsible for initiating helminth-induced type-2 responses, through activation of ILC2s. Additional receptors reported to be highly expressed by ILC2s and required for their expansion and function include the tumor necrosis factor (TNF)-receptor superfamily member DR3 (TNFRSF25) and the IL-9R. In the absence of TL1A ligation to DR3, there is significantly reduced ILC2 expansion, type-2 cytokine production and N. brasiliensis expulsion (74), whereas IL-9R signaling was required for ILC2 accumulation, expulsion of N. brasiliensis and...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 26 November 2018Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Li-Bo Zhang, Min HeAbstractBackgroundOver the years, mesenchymal stromal (stem) cells (MSCs) have been pre-clinically applied in the treatment of variety kinds of diseases including asthma and chronic lung diseases. Aim of the current study was to systematically review and to conduct meta-analysis on the published studies of MSC treatment in asthma animal models.MethodsPublications on the MSC and asthma treatment was thoroughly searched in the electronic databases. Statistical analysis was then performed using the ...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
The last two authors contributed equallyElevated soluble Stimulation-2 (sST2), the decoy IL-33 receptor, in plasma/serum post-HSCT is a biomarker for death due to GvHD. ST2 is the product of IL1RL1 (2q12.1) and this ~.5Mb region contains>300 single nucleotide polymorphisms (SNPs) significantly associated (P
Source: Blood - Category: Hematology Authors: Tags: 732. Clinical Allogeneic Transplantation: Results: Optimizing Outcomes After Allogeneic Transplantation Source Type: research
This study provides a therapeutic strategy for targeting asthma inflammation.Graphical Abstract
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 18 October 2018Source: Microvascular ResearchAuthor(s): Reza Rahbarghazi, Rana Keyhanmanesh, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi AhmadiAbstractObjectivesAlthough excitements related to stem cell therapeutic outcomes have been highlighted enormously in asthma, the vast majority of works were conducted by researchers in animal models. Elucidating the mechanisms underlying the therapeutic effects of MSCs in asthmatic rats will provide a rational basis for assuring maximal safety of future clinical application of stem cells. In the current study, we sought to investigate the possibl...
Source: Microvascular Research - Category: Biochemistry Source Type: research
Publication date: 1 November 2018Source: Life Sciences, Volume 212Author(s): Rana Keyhanmanesh, Reza Rahbarghazi, Mohammad Reza Aslani, Mehdi Hassanpour, Mahdi AhmadiAbstractAimsWith respect to recent advantage in stem cell application, given the concern reported previously after stem cell transplantation, mesenchymal stem cell-derived conditioned media (MSC-CM) could be a potential approach to guarantee more safety and efficient outcomes than the current stem cell–based regenerative therapies.Main methodsMale rats were assigned into four experimental groups (n = 6); healthy rats (C group), OVA sensitized rats (S...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Hosseinirad H, Rashidi M, Moghaddam MM, Tebyanian H, Nouraei S, Mirhosseini SA, Rasouli M, Habibian S Abstract The respiratory system is a complex group of organs in the human body, all of which are necessary in breathing. Due to its special anatomy and composition, after exposure to various damaging factors such as micro particles, carbon granules and toxic gases, the respiratory system can be affected by a variety of damage without return to its original state. Currently, the prevalence of lung diseases, including asthma, and chronic obstructive pulmonary diseases, such as emphysema, has increased remark...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
AbstractAchieving the optimal clinical outcome of mesenchymal stem cells (MSCs) is particularly dependent on fundamental understanding of therapeutic mechanisms. The current study was focused on the possible mechanisms by which rat bone marrow-derived mesenchymal stem cells (rBMMSCs) and/or conditioned media (CM) display broad immunomodulatory properties for ameliorating of asthma-related pathological changes. Male rats were divided equally into four experimental groups (n = 6): healthy rats received 50 μl PBS intravenously (group C), sensitized rats received 50 μl PBS intravenously (group OVA...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
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