The evolution of arthritic knees

(Harvard University) Scientists have identified the genetic switches regulating knee development in mouse and human, explored their evolution, probed their links to bipedalism and osteoarthritis, and confirmed that a mutation in one switch gives rise to the disease. The findings could lead to screening for subtle shape alterations and genetic variations earlier in life that might predispose a person to risk. The methods could be used to explore genetic links between any advantageous trait and potential pathology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news