Toxoplasmosis and behavioural changes (French translation of the article).

[Toxoplasmosis and behavioural changes (French translation of the article)]. J Fr Ophtalmol. 2020 Apr 02;: Authors: Desmettre T Abstract Nearly one-third of the planet's population is affected by T. gondii infection. In ophthalmology, toxoplasmosis is even considered to be the most common cause of posterior uveitis of infectious origin. Humans are only an intermediate host, and T. gondii needs to infect cats for its sexual reproduction. All the elements increasing the risk of predation by the definitive host are then favourable to the parasite. Numerous experimental animal model studies have shown that T. gondii infection is associated with predatory risk behaviours such as an attraction of infected mice to cat urine. Infection with the parasite is associated with a demethylation of the promoters of certain genes in the cerebral amygdala of the intermediate hosts, modifying dopaminergic circuits associated with fear. Similarly, T. gondii has been linked to behavioural changes in humans. Toxoplasma infection is classically associated with the frequency of schizophrenia, suicide attempts or "road rage." A more recent study shows that toxoplasma infection prevalence was a consistent, positive predictor of entrepreneurial activity. Fear of failure would be less important in infected individuals, who are more willing than others to start their own business. These elements shed interesting light on behaviours and their possible rel...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

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Authors: Desmettre T Abstract Nearly one-third of the planet's population is affected by Toxoplasma gondii infection. In ophthalmology, toxoplasmosis is even considered to be the most common cause of posterior uveitis of infectious origin. Humans are only an intermediate host and T. gondii needs to infect cats for its sexual reproduction. All the elements increasing the risk of predation by the definitive host are then favourable to the parasite. Numerous experimental animal model studies have shown that T. gondii infection is associated with predatory risk behaviours such as an attraction of infected mic...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Andreas Seyfang Maureen W. Groer Braxton D. Mitchell Teodor T. Postolache Toxoplasma gondii (T. gondii) is an intracellular parasite infecting one third of the world’s population. Latent T. gondii infection has been associated with mental illness, including schizophrenia and suicidal behavior. T. gondii IgG antibody titers were measured via ELISA. The heritability of T. gondii IgG was estimated using a mixed model that included fixed effects for age and sex and random kinship effect. Of 2017 Old Order Amish participants, 1098 had positive titers (54.4%). The heritability for T. gondii serointensity was ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions Toxoplasma gondii infection induces a strong innate and adaptive immune response. While the innate immunity is important for controlling the early stages of the infection (Yarovinsky, 2014), the adaptive immunity is critical for restricting the parasite replication during the later stages (Gazzinelli et al., 1992). Amongst the adaptive immune subsets, CD8 T cells are the primary effector cells while CD4 T cells play an essential helper role to maintain long-term immunity (Casciotti et al., 2002). Notwithstanding, a robust CD8 T cell immunity induced during acute phase of infection, does not result in the total...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
This study examines the effect of employment on delinquent behavior among young people in “hidden situations”. Both quantitative and qualitative methods were used, and 588 young people in these hidden situations were investigated. Results showed that some of them had employment; their employment status constituted a mediating effect on preventing them from being involved in delinquent behavior. Also, participants who had work explained the reasons for not being involved in delinquent behavior. These results reflect that whether young people in hidden situation involve in delinquent behavior depends on their emp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Toxoplasma gondii is an intracellular parasite, infecting one-third of the world ’s population. Exposure via food and non-food related factors (i.e., contact with cat feces) is required for infection, however, host genetic factors may play a role in susceptibility. Latent T. gondii infection has been consistently associated with mental illness, including schizophrenia, bipolar disorder, suicidal behavior and its endophenotypes impulsivity and aggression, and less consistently associated with depression.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Toxoplasma gondii is an intracellular parasite, infecting one-third of the world ’s population. Exposure via food and non-food related factors (i.e., contact with cat feces) is required for infection, however, host genetic factors may play a role in susceptibility. Latent T. gondii infection has been consistently associated with mental illness, including schizophrenia, bipolar disorder, suicidal behavior and its endophenotypes impulsivity and aggression, and less consistently associated with depression.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Conclusions: The studies conducted to date were limited in number with suggestive but methodologically weak findings related to chronic exposure. Given the wide-scale use of neonics, more studies are needed to fully understand their effects on human health. Citation: Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Effects of neonicotinoid pesticide exposure on human health: a systematic review. Environ Health Perspect 125:155–162; http://dx.doi.org/10.1289/EHP515 Address correspondence to M.J. Perry, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington Un...
Source: EHP Research - Category: Environmental Health Authors: Tags: Reviews February 2017 Source Type: research
Publication date: Available online 12 April 2016 Source:Microbes and Infection Author(s): Naomi Tanaka, Danah Ashour, Edward Dratz, Sandra Halonen Toxoplasma gondii is a ubiquitous protozoan parasite with approximately one-third of the worlds' population chronically infected. In chronically infected individuals, the parasite resides primarily in cysts within neurons in the central nervous system. The chronic infection in immunocompetent individuals has been considered to be asymptomatic but increasing evidence indicates the chronic infection can lead to neuropsychiatric disorders such as Schizophrenia, prenatal depre...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
BACKGROUND: Toxoplasma gondii is an intracellular protozoan parasite with zoonotic potential that causes acute and chronic diseases, which has been associated with schizophrenia, depression, bipolar disorder, and suicidal behavior. Military personnel may b...
Source: SafetyLit: All (Unduplicated) - Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
ConclusionThis study aimed to replicate the researchers' previous findings, which suggest that cat ownership in childhood is a possible risk factor for developing schizophrenia in later life. This study is able to draw a link, but cannot prove cause and effect. There is a suggestion that this link may be due to the parasite T. gondii, which is transferred from cats to humans if they come into contact with the faeces of infected cats, or eating or drinking contaminated food or water.Even if this link between cats and mental illness was proven to be true, contact is unavoidable; children could become infected by playing in a...
Source: NHS News Feed - Category: Consumer Health News Tags: Lifestyle/exercise Mental health Pregnancy/child Source Type: news
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