Daily adaptive proton therapy: Is it appropriate to use analytical dose calculations for plan adaption?

The accuracy of analytical dose calculations (ADC) and dose uncertainties resulting from anatomical changes are both limiting factors in proton therapy. For the latter, rapid plan adaption is necessary, whereas for the former, Monte Carlo (MC) approaches are instead being increasingly recommended. These however are inherently slower than analytical approaches, potentially limiting the ability to rapidly adapt plans. Here, we compare the clinical relevance of uncertainties resulting from both.

Source: International Journal of Radiation Oncology * Biology * Physics - April 6, 2020 Category: Radiology Authors: Lena Nenoff, Michael Matter, Agnes Geetanjali Jarhall, Carla Winterhalter, Jenny Gorgisyan, Mirjana Josipovic, Gitte F. Persson, Per Munck af Rosenschold, Damien Charles Weber, Antony John Lomax, Francesca Albertini Source Type: research