Concordance and Discordance in the Geographic Distribution of Childhood Obesity and Pediatric Type 2 Diabetes in New York City

Publication date: Available online 7 April 2020Source: Academic PediatricsAuthor(s): Marcela Osorio, Christian A. Koziatek, Mary Pat Gallagher, Jessie Recaii, Meryle Weinstein, Lorna E. Thorpe, Brian Elbel, David C. Lee
Source: Academic Pediatrics - Category: Pediatrics Source Type: research

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Purpose of review To give an updated review on the underlying mechanisms and clinical effects of improved glucose control after bariatric surgery. Recent findings The basic principles of the mechanism for the metabolic effects of bariatric surgery can be categorized into calorie restriction, deviation of nutrients, and reduced amounts of adipose tissue. Recent findings suggest the importance of early changes following deviation of nutrients to more distal parts of the small bowel resulting in altered release of gastrointestinal hormones, altered gut microbiota, and weight-reduction. In the long-term, loss of adipose t...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: CARBOHYDRATES: Edited by Bettina Mittendorfer and Olle Ljungqvist Source Type: research
Background: Treatment with a duodenal-jejunal bypass sleeve (DJBS) induces clinically significant weight loss, but little is known about the mechanisms of action of this device. Aim: The aim of this study was to characterize the mechanisms of action of the DJBS and determine the durability of weight loss and metabolic improvements. Materials and Methods: We studied a cohort of 19 subjects with severe obesity and type 2 diabetes (baseline body mass index: 43.7±5.3 kg/m2). Anthropometry, body composition, blood pressure, biochemical measures, and dietary intake were monitored for 48 weeks after DJBS imp...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
Publication date: Available online 6 June 2020Source: Canadian Journal of DiabetesAuthor(s): Jessie Benson, Cameron Severn, Julia Hudnut-Beumler, Stacey L. Simon, Natalie Abramson, Lauren B. Shomaker, Lauren D. Gulley, Anya Taylor, Megan M. Kelsey, Kristen J. Nadeau, Philip Zeitler, Laura Pyle, Melanie Cree-Green
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
CONCLUSION: We conclude that visfatin in serum may be a new independent potential marker of AMI. PMID: 32495751 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Conclusions: This study will help to build proposals that aim at providing high quality RCTs in the management of LSGT in OP with T2DM. Systematic review registration: INPLASY202040128.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Despite high-quality evidence highlighting metabolic surgery as an effective treatment option for type 2 diabetes mellitus (T2DM), the number of patients receiving bariatric surgery (BS) remains low. Since the introduction of the Diabetes Surgery Summit II (DSS-II) eligibility criteria, data on eligibility rates for BS in T2DM cohorts remain scarce. The aims of the present study were to examine in a real-world clinical setting: (i) what is the percentage of T2DM patients visiting diabetes outpatient clinics who meet the DSS-II eligibility criteria, (ii) how many of these have been informed about the option of BS, and (iii)...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Background: Acarbose and dipeptidyl peptidase-4 inhibitors (DPP-4is) have several similarities regarding their efficacy. Assessing the hypoglycemic and weight-loss effects, as well as the tolerability between them at their optimal dosages, could provide a better management of adult type 2 diabetics.Methods: We performed a systematic review and network meta-analysis (NMA) on randomized controlled trials that were identified from the databases of EMBASE, MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, Conference Proceedings Citation Index, ClinicalTrials.gov, China National Knowledge Infrastructure, ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Zhang C, Cai W, Zhao H, Zhu M, Cui J, Sun Z Abstract To compare the clinical efficacy of gastric bypass in obese patients with T2DM with different BMI. Serum leptin, adiponectin, triglyceride (TG), cholesterol (CHOL) were measured as the indicators to show clinical efficacy after laparoscopic gastric bypass surgery (LRYGB). For patients with high BMI and patients with low BMI, the therapeutic effect of LRYGB surgical diabetes is more significant. The postoperative remission rate of diabetes in the high BMI group was not correlated with the preoperative lipid metabolism index but was positively correlated w...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Conclusions: In this population-based study, the detection of breast cancer gradually increased with GLP-1 RA weight loss categories, particularly among those achieving>10% weight loss. These results are consistent with the hypothesis that substantial weight loss with GLP-1 RAs may improve detection of breast cancer among obese patients with type 2 diabetes.
Source: Epidemiology - Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research
Authors: Kadayifci FZ, Haggard S, Jeon S, Ranard K, Tao D, Pan YX Abstract Type 2 Diabetes Mellitus is an increasing public health problem that poses a severe social and economic burden affecting both developed and developing countries. Defects in insulin signaling itself are among the earliest indications that an individual is predisposed to the development of insulin resistance and subsequently Type 2 Diabetes Mellitus. To date, however, the underlying molecular mechanisms which result in resistance to the actions of insulin are poorly understood. Furthermore, it has been shown that maternal obesity is associated...
Source: Current Genomics - Category: Genetics & Stem Cells Tags: Curr Genomics Source Type: research
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