The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125

ConclusionsSerum HE4 levels can potentially be used as a marker to differentiate between benign and malignant ovarian disease with elevated serum CA125 levels. The high specificity of HE4 was superior in identifying benign ovarian disease. We recommend increasing the cutoff values of HE4 in premenopausal patients and decreasing the cutoff values in postmenopausal patients for increased accuracy in the differential diagnosis of patients with elevated CA125 levels.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research